Identification of key genes and signaling pathways based on transcriptomic studies of aerobic and resistance training interventions in sarcopenia in SAMP8 mice

Abstract

We examined the effects of resistance and aerobic exercise on the gene expression and biometabolic processes of aging skeletal muscle in senescence-accelerated mouse/prone 8 mice, a model of sarcopenia, and compared them with senescence-accelerated mouse/resistant 1 mice acting as controls. We found that exercise improved muscle strength, endurance, fiber size, also modulated genes and pathways related to synaptic transmission, potassium transport, JAK-STAT signaling, and PI3K-Akt signaling. Our results suggested that BDNF, JAK2, RhoC, Myh6, Stat5a, Tnnc1, and other genes may mediate the beneficial effects of exercise on sarcopenia through these pathways.

Keywords

Resistance training / Aerobic training / Sarcopenia / Transcriptome

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The authors thank all the laboratory members (Qingsong Liu, Junjie Zhu, Zeting Fu, Yan Zhang, and Yicheng Wang) for their help and technical support. We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.