Optimal exercise intensity and volume to impact rats with Traditional Chinese Medicine phlegm-dampness constitution

Abstract

Objective

Conclusion

Keywords

Constitution of traditional Chinese medicine / Aerobic exercise / Exercise intensity and volume / Phlegm-dampness constitution

We aim to investigate the effects of different exercise intensities and volumes on Phlegm-dampness constitution (PDC).

Methods

The rats were fed with high-fat food and lived in 75%-85% humidity for 6 weeks to establish the model of PDC. Then PDC rats were screened and intervened by varying exercise intensities for 8 weeks. Weight, constitution scores, blood and liver tissues were collected to detect the concentration of serum total cholesterol (Tch), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), homocysteine (Hcy), blood glucose (GLU), alanine transaminase (ALT) and percentage of lipid droplet area in liver tissue (PLDA).

Results

The weight, Tch, TG, HDL-C, LDL-C, Hcy, GLU, and ALT of rats in moderate-intensity exercise group returned to normal. The rats with high-intensity or low-intensity exercise did not recover as well as moderate-intensity.

Different exercise intensities and volumes have different effects on PDC, moderate-intensity exercise over an 8-week intervention is most appropriate.

Ethical approval statement

We promise that the study was performed according to the international, national and institutional rules considering animal experiments, clinical studies and biodiversity rights. The study protocol was approved by the Animal Center of the Sichuan Academy of Chinese Medical Sciences. Certificate No.: SYXK (C) 2019-036.

Submission statement

The manuscript has not been published and is not under consideration for publication elsewhere.

Authors' contributions

Yaming Yu and Zhangmeng Xu conceived the study, Zhangmeng Xu, Yong Chen, Jing Zhou, Donghong Feng performed animal experiments, Chenjian Tang, and Tao Li performed data collection and analysis, Zhangmeng Xu and Yaming Yu wrote the manuscript, Zhangmeng Xu and Duoduo Yu revised the manuscript, all the authors reviewed manuscript to determine the final version.

Conflict of interest

None competing interests of all authors.

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