A 24 hour naproxen dose on gastrointestinal distress and performance during cycling in the heat

Abstract

Using a double-blind, randomized and counterbalanced, cross-over design, we assessed naproxen's effects on gastrointestinal (GI) distress and performance in eleven volunteers (6 male, 5 female). Participants completed 4 trials: 1) placebo and ambient); 2) placebo and heat; 3) naproxen and ambient; and 4) naproxen and heat. Independent variables were one placebo or 220 mg naproxen pill every 8 h (h) for 24 h and ambient (22.7 ± 1.8°C) or thermal environment (35.7 ± 1.3°C). Participants cycled 80 min at a steady heart rate then 10 min for maximum distance. Perceived exertion was measured throughout cycling. Gastrointestinal distress was assessed pre-, during, post-, 3 h post-, and 24 h post-cycling using a GI index for upper, lower, and systemic symptoms. No statistically significant differences occurred between conditions at any time for GI symptoms or perceived exertion, distance, or heart rate during maximum effort. A 24 h naproxen dose did not significantly affect performance or cause more frequent or serious GI distress when participants were euhydrated and cycling at moderate intensity in a thermal environment.

Keywords

NSAID / Gastrointestinal bleeding / Heart rate / Perceived exertion

Authors’ contributions

Conceptualization and Study Design: DME, JMD, SCLC, TMTM, CCE; Data Acquisition: DME, TMTM, CEP, CCE, JDB, JVS; Data Analysis and Interpretation: DME, JMD, SCLC, TMTM; Drafting Manuscript: DME; Critical Revision of Manuscript: DME, JMD, SCLC, TMTM, CEP, CCE, JDB, JVS; Final Approval of Manuscript: DME, JMD, SCLC, TMTM, CEP, CCE, JDB, JVS.

Conflict of interest

Portions of this study were supported by funding from the American College of Sports Medicine Foundation and the National Athletic Trainers’ Association Research and Education Foundation. The agencies had no role in the study design, data collection or analysis, or the writing and submitting for publication. The authors have no other conflict of interests to disclose.

Submission statement

This manuscript has not been published and is not under consideration for publication elsewhere.

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