Interpersonal computational modelling of social synchrony in schizophrenia and beyond

Keywords

Interpersonal psychiatry / Computational psychiatry / Social coordination / Interpersonal computational modelling / Psychosis / Autism / Dissociation

Author contributions

Gwynnevere Suter (Conceptualization, Investigation, Visualization, Writing – original draft, Writing – review & editing), Emma Černis (Funding acquisition, Supervision, Writing – review & editing), and Lei Zhang (Conceptualization, Funding acquisition, Supervision, Writing – review & editing).

Conflicts of interest

We declare no conflicts of interest.

Acknowledgements

We thank the College of Life and Environmental Sciences at the University of Birmingham for providing the LES PhD Studentship, which funded this research highlight. This work was also partially supported by the Wellcome Data Science Ideathon Grant (228268/Z/23/Z) and the Royal Society International Exchanges Award (IES\R3\243253) to L.Z.

References

[1] Acebrón JA, Bonilla LL, et al. (2005) The Kuramoto model: a simple paradigm for synchronization phenomena. Rev Mod Phys. 77:137-85. https://doi.org/10.1103/RevModPhys.77.137.

[2] Alvi T, Kumar D, Tabak BA. (2022) Social anxiety and behavioral assessments of social cognition: a systematic review. J Affect Disord. 311:17-30. https://doi.org/10.1016/j.jad.2022.04.130.

[3] American Psychiatric Association. (2013) Diagnostic and Statistical Manual of Mental Disorders)(5th ed.). https://doi.org/10.1176/appi.books.9780890425596.

[4] Bateson G, Jackson DD, Haley J., et al. (1956) Toward a theory of schizophrenia. Behav Sci. 1:251. Periodicals Archive Online; Periodicals Index Online.

[5] Černis E, Ehlers A, Freeman D. (2022) Psychological mechanisms connected to dissociation: generating hypotheses using network analyses. J Psychiatr Res. 148:165-73. https://doi.org/10.1016/j.jpsychires.2022.01.049.

[6] Cerullo S, Fulceri F, Muratori F., et al. (2021) Acting with shared intentions: a systematic review on joint action coordination in Autism Spectrum Disorder. Brain Cogn. 149:105693. https://doi.org/10.1016/j.bandc.2021.105693.

[7] Chen Y-L, Senande LL, Thorsen M., et al. (2021) Peer preferences and characteristics of same-group and cross-group social interactions among autistic and non-autistic adolescents. Autism. 25:1885-900. https://doi.org/10.1177/13623613211005918.

[8] Chisholm K, Lin A, Abu-Akel A., et al. (2015) The association between autism and schizophrenia spectrum disorders: a review of eight alternate models of co-occurrence. Neurosci Biobehav Rev. 55:173-83. https://doi.org/10.1016/j.neubiorev.2015.04.012.

[9] Crespi B, Badcock C. (2008) Psychosis and autism as diametrical disorders of the social brain. Behav Brain Sci. 31:241-61. Cambridge Core. https://doi.org/10.1017/S0140525×08004214.

[10] Dean DJ, Scott J, Park S. (2021) Interpersonal coordination in schizophrenia: a scoping review of the literature. Schizophr Bull. 47:1544-56. https://doi.org/10.1093/schbul/sbab072.

[11] Delaherche E, Chetouani M, Mahdhaoui A, et al. (2012) Interpersonal synchrony: a survey of evaluation methods across disciplines. IEEE Trans Affective Comput. 3:349-65. https://doi.org/10.1109/T-AFFC.2012.12.

[12] Derntl B, Habel U. (2011) Deficits in social cognition: a marker for psychiatric disorders?. Eur Arch Psychiatry Clin Neurosci. 261:145. https://doi.org/10.1007/s00406-011-0244-0.

[13] Dumas G. (2022) From inter-brain connectivity to inter-personal psychiatry. World Psychiatry. 21:214-5. https://doi.org/10.1002/wps.20987.

[14] Endo T, Sugiyama T, Someya T. (2006) Attention-deficit/hyperactivity disorder and dissociative disorder among abused children. Psychiatry Clin Neurosci. 60:434-8. https://doi.org/10.1111/j.1440-1819.2006.01528.x.

[15] Fairchild G, Hawes DJ, Frick PJ., et al. (2019) Conduct disorder. Nat Rev Dis Primers. 5:43. https://doi.org/10.1038/s41572-019-0095-y.

[16] Freeman D, Garety PA, Kuipers E., et al. (2002) A cognitive model of persecutory delusions. Br J Clin Psychol. 41:331-47. https://doi.org/10.1348/014466502760387461.

[17] Freeman D. (2016) Persecutory delusions: a cognitive perspective on understanding and treatment. The Lancet Psychiatry. 3:685-92. https://doi.org/10.1016/S2215-0366(16)00066-3.

[18] Friston KJ, Stephan KE, Montague R., et al. (2014) Computational psychiatry: the brain as a phantastic organ. The Lancet Psychiatry. 1:148-58. https://doi.org/10.1016/S2215-0366(14)70275-5.

[19] Fuchs P, Nussbeck FW, Meuwly N., et al. (2017) Analyzing dyadic sequence data—Research questions and implied statistical models. Front Psychol. 8. 429 https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2017.00429

[20] Green MF, Horan WP, Lee J. (2015) Social cognition in schizophrenia. Nat Rev Neurosci. 16:620-31. https://doi.org/10.1038/nrn4005.

[21] Gvirts Problovski HZ, Lavi D, Yozevitch R., et al. (2021) Impairments of interpersonal synchrony evident in attention deficit hyperactivity disorder (ADHD). Acta Psychol (Amst). 212:103210. https://doi.org/10.1016/j.actpsy.2020.103210.

[22] Heggli OA, Cabral J, Konvalinka I., et al. (2019) A Kuramoto model of self-other integration across interpersonal synchronization strategies. PLoS Comput Biol. 15:e1007422. https://doi.org/10.1371/journal.pcbi.1007422.

[23] Huys QJM, Maia TV, Frank MJ. (2016) Computational psychiatry as a bridge from neuroscience to clinical applications. Nat Neurosci. 19:404-13. https://doi.org/10.1038/nn.4238.

[24] Insel T, Cuthbert B, Garvey M., et al. (2010) Research domain criteria (RDoC): toward a new classification framework for Research on mental disorders. Am J Psychiatry. 167:748-51. https://doi.org/10.1176/appi.ajp.2010.09091379.

[25] Irwin HJ. (1999) Pathological and nonpathological dissociation: the relevance of childhood trauma. J Psychol. 133:157-64. https://doi.org/10.1080/00223989909599730.

[26] Kawasaki M, Kitajo K, Fukao K., et al. (2017) Frontal theta activation during motor synchronization in autism. Sci Rep. 7:15034. https://doi.org/10.1038/s41598-017-14508-4.

[27] Kelleher I, Keeley H, Corcoran P., et al. (2013) Childhood trauma and psychosis in a prospective cohort study: cause, effect, and directionality. Am J Psychiatry. 170:734-41. https://doi.org/10.1176/appi.ajp.2012.12091169.

[28] King BH, Lord C. (2011) Is schizophrenia on the autism spectrum?. Brain Res. 1380:34-41. https://doi.org/10.1016/j.brainres.2010.11.031.

[29] Konvalinka I, Vuust P, Roepstorff A., et al. (2010) Follow you, Follow me: continuous mutual prediction and adaptation in joint tapping. Q J Exp Psychol. 63:2220-30. https://doi.org/10.1080/17470218.2010.497843.

[30] Kotov R, Krueger RF, Watson D., et al. (2017) The Hierarchical Taxonomy of Psychopathology (HiTOP): a dimensional alternative to traditional nosologies. J Abnorm Psychol. 126:454-77. https://doi.org/10.1037/abn0000258.

[31] Lyssenko L, Schmahl C, Bockhacker L., et al. (2018) Dissociation in psychiatric disorders: a meta-analysis of studies using the Dissociative Experiences scale. Am J Psychiatry. 175:37-46. https://doi.org/10.1176/appi.ajp.2017.17010025.

[32] Macpherson MC, Marie D, Schön S., et al. (2020) Evaluating the interplay between subclinical levels of mental health symptoms and coordination dynamics. Br J Psychol. 111:782-804. https://doi.org/10.1111/bjop.12426.

[33] Macpherson MC, Miles LK. (2023) Synchrony and mental health: investigating the negative association between interpersonal coordination and subclinical variation in autism and social anxiety. J Exp Soc Psychol. 105:104439. https://doi.org/10.1016/j.jesp.2022.104439.

[34] Mahoney CT, Benight CC. (2019) The temporal relationship between coping self-efficacy and dissociation in undergraduate students. J Trauma Dissociation. 20:471-87. https://doi.org/10.1080/15299732.2019.1597805.

[35] Matsumoto T, Imamura F. (2007) Association between childhood attention-deficit-hyperactivity symptoms and adulthood dissociation in male inmates: preliminary report. Psychiatry Clin Neurosci. 61:444-6. https://doi.org/10.1111/j.1440-1819.2007.01683.x.

[36] Middleton W, Dorahy MJ, Moskowitz A. (2018) Historical conceptions of dissociative and psychotic disorders. In Psychosis, Trauma and Dissociation. Hoboken, New Jersey: Wiley-Blackwell, (pp.31-42.). https://doi.org/10.1002/9781118585948.ch2.

[37] Moskowitz A, Heim G. (2018) The role of dissociation in the historical concept of schizophrenia. In Psychosis, Trauma and Dissociation. Hoboken, New Jersey: Wiley-Blackwell, (pp.55-67.). https://doi.org/10.1002/9781118585948.ch4.

[38] Moskowitz A, Montirosso R. (2018) Childhood experiences and delusions. In Psychosis, Trauma and Dissociation. Hoboken, New Jersey: Wiley-Blackwell, (pp.117-40.). https://doi.org/10.1002/9781118585948.ch8.

[39] Nieves N. (2020) I wanna rock with you: the facilitative effects of interpersonal synchrony and interoceptive awareness on self-regulation among traumatized individuals in romantic couples (Publication number 2428066334) [Ph.D. Thesis, The New School]. ProQuest Dissertations & Theses Global https://www.proquest.com/docview/2428066334

[40] O'Driscoll C, Laing J, Mason O. (2014) Cognitive emotion regulation strategies, alexithymia and dissociation in schizophrenia, a review and meta-analysis. Clin Psychol Rev. 34:482-95. https://doi.org/10.1016/j.cpr.2014.07.002.

[41] Olarewaju E, Dumas G, Palaniyappan L. (2023) Disorganized communication and social dysfunction in schizophrenia: emerging concepts and methods. Curr Psychiatry Rep. 25:671-81. https://doi.org/10.1007/s11920-023-01462-4.

[42] Pan Y, Vinding MC, Zhang L., et al. (2023) A brain-to-brain mechanism for social transmission of threat learning. Adv Sci. 10:2304037. https://doi.org/10.1002/advs.202304037.

[43] Pan Y, Wen Y, Jin J., et al. (2023) The interpersonal computational psychiatry of social coordination in schizophrenia. The Lancet Psychiatry. 10:801-8. https://doi.org/10.1016/S2215-0366(23)00146-3.

[44] Pienkos E, Sass L. (2022) Robbed of my life”: the Felt loss of familiar and engaged presence in depersonalization/derealization disorder. J Phenomenol Psychol. 53:51-81. https://doi.org/10.1163/15691624-20221398.

[45] Redcay E, Schilbach L. (2019) Using second-person neuroscience to elucidate the mechanisms of social interaction. Nat Rev Neurosci. 20:495-505. https://doi.org/10.1038/s41583-019-0179-4.

[46] Reuben K, Parish A. (2022) Dissociation in Autism Spectrum Disorders:an Under-recognized Symptom. Perspectives of dissociative identity response: Ethical, historical, and cultural issues. HWC Press, LLC Bartlesville, Oklahoma, USA151-186.

[47] Roepke S, Vater A, Preißler S., et al. (2013) Social cognition in borderline personality disorder. Front Neurosci. 6.195 https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2012.00195

[48] Rokita KI, Dauvermann MR, Donohoe G. (2018) Early life experiences and social cognition in major psychiatric disorders: a systematic review. Eur Psychiatry. 53:123-33. https://doi.org/10.1016/j.eurpsy.2018.06.006.

[49] Sohail A, Zhang L. (2024) Informing the treatment of social anxiety disorder with computational and neuroimaging data. Psychoradiology. 4:kkae010.

[50] Stanton KJ, Denietolis B, Goodwin BJ., et al. (2020) Childhood trauma and psychosis: an updated review. Child Adolesc Psychiatr Clin N Am. 29:115-29. https://doi.org/10.1016/j.chc.2019.08.004.

[51] Sterzer P, Adams RA, Fletcher P., et al. (2018) The predictive coding account of psychosis. Biol Psychiatry. 84:634-43.

[52] Terock J, Van der Auwera S, Janowitz D., et al. (2016) From childhood trauma to adult dissociation: the role of PTSD and alexithymia. Psychopathology. 49:374-82. https://doi.org/10.1159/000449004.

[53] Wilquin H, Delevoye-Turrell Y, Dione M., et al. (2018) Motor synchronization in patients with schizophrenia: preserved time representation with abnormalities in predictive timing. Front Hum Neurosci. 12. 193 https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2018.00193

[54] Yozevitch R, Dahan A, Seada T., et al. (2023) Classifying interpersonal synchronization states using a data-driven approach: implications for social interaction understanding. Sci Rep. 13:11150. https://doi.org/10.1038/s41598-023-37316-5.

[55] Zhang L. (2023) Examining mental disorders with computational neuroscience. Nature Rev Psychol. 2:4-4. https://doi.org/10.1038/s44159-022-00131-2.