Novel homozygous mutation in the FANCA gene (c.2222G>A) in a Chinese girl of Fanconi anemia

Wen Xianhao; Qin Hongcheng; Liao Meiling; Guan Xianmin

doi:10.1002/pdi3.63

Pediatric Discovery ›› 2024, Vol. 2 ›› Issue (1) :e63 DOI: 10.1002/pdi3.63

CASE REPORT

Novel homozygous mutation in the FANCA gene (c.2222G>A) in a Chinese girl of Fanconi anemia

Wen Xianhao ¹^,²^,³^,⁴^,^†
, Qin Hongcheng ⁵
, Liao Meiling ¹^,²^,³^,⁴
, Guan Xianmin ¹^,²^,³^,⁴

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Abstract

Fanconi anemia is the most common inherited bone marrow failure syndrome. Its clinical manifestations include congenital dysplasia, bone marrow hematopoietic failure and tumor susceptibility. At present, there are 23 related gene abnormalities, among which FANCA is the most common. We report a case of a Chinese girl with bone dysplasia and aplastic anemia. The next-generation sequencing results showed a homozygous mutation in the FANCA gene (c.2222G > A), which was predicted to be a pathogenic mutation based on protein function. This mutation at this site has not been reported in the previous literature. The diagnosis of Fanconi anemia should be determined with combined clinical, chromosome breakage test and gene sequencing results.

Keywords

FANCA gene / Fanconi anemia / next-generation sequencing

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Wen Xianhao, Qin Hongcheng, Liao Meiling, Guan Xianmin. Novel homozygous mutation in the FANCA gene (c.2222G>A) in a Chinese girl of Fanconi anemia. Pediatric Discovery, 2024, 2(1): e63 DOI:10.1002/pdi3.63

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References

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