Targeting facial aging with nano and regenerative technologies and procedures

Abstract

This study reviews information about the most novel ideas and modalities being incorporated into facial and neck cosmetic care. We seek to identify trends and developments within these areas as well as perceptions of plastic surgeons regarding their probable significance, and discussion on how these modalities may impact future practice patterns. It is hypothesized that nano and regenerative technologies are considered the most “hopeful”. Emerging invasive and non-invasive modalities utilizing nano and regenerative concepts were reviewed. We intentionally sought to investigate approaches to beautification, including maintenance and reversal of signs of aging, utilizing methods lacking an established level of evidence. This included promising modalities which are currently at the investigational stage. Twelve board-certified plastic surgeons were surveyed regarding the clinical importance of twelve concepts and their expected impact on facial and neck rejuvenation. Scientific and technological creativity in aesthetics is rapidly changing, and the efficacy of innovations and safety margins are improving. Nano and regenerative medicine-based technologies and procedures were ranked most promising for the future of cosmetics. Their potential applications and research were reviewed in the context of surgical and non-surgical modalities in clinical practice. There has been an advent of new approaches to facial and neck aesthetic surgery and tissue care, which is well-beyond just skin care. With this new level of knowledge regarding variability in care responses and indications for procedures on an almost “molecular level”, personalized and precise aesthetic surgery and medicine are quickly becoming a reality.

Keywords

Face / neck rejuvenation / nano / regenerative technologies

References

[1] Lohani A,Joshi H,Karki N.Nanotechnology-based cosmeceuticals..ISRN Dermatol2014;2014:843687 PMCID:PMC4055113

[2] Gaur M,Lunyak VV.Mesenchymal stem cells from adipose tissue in clinical applications for dermatological applications and skin aging..Int J Mol Sci2017;18:1-29

[3] Dobke M,Vargas F.Skin aging and beauty exploring the gut microbiota connection..J Aesth Rec Surg2019;5:1-3

[4] Mandal BB.Self-assembled silk sericin/poloxamer nanoparticles are nanocarriers of hydrophobic and hydrophilic drugs for targeted delivery..Nanotechnology2009;20:355101

[5] Goldfaden R, Goldfaden G. Target wrinkle formation with novel peptides. Life Extension 2014. Available from: https://www.lifeextension.com/magazine/2014/4/target-wrinkle-formation-with-novel-peptides [Last accessed on 10 Jan 2020]

[6] Limongi T,Racca L,Tritta S.Improving dispersal of therapeutic nanoparticles in the human body..Nanomedicine (Lond)2019;14:797-801

[7] Cohen SR.Injectable tissue replacement and regeneration: anatomic fat grafting to restore decayed facial tissues..Plast Reconstr Surg Glob Open2019;7:1-11 PMCID:PMC6756675

[8] Terlizzi V,Burgess JK,Hamsen MC.The pericytic phenotype of adipose tissue-derived stromal cells is promoted by NOTCH2..Stem Cells2018;36:240-51

[9] Prow TW,Lin LL,Butler M.Nanoparticles and microparticles for skin drug delivery..Adv Drug Deliv Rev2011;63:470-91

[10] Samadi P,Khoshinani HM.The use of platelet-rich plasma in aesthetic and regenerative medicine: a comprehensive review..Aesthetic Plast Surg2019;43:803-14

[11] Verma S,Kumar N.Nanomaterials for regenerative medicine..Nanomedicine (Lond)2011;6:157-81

[12] Jin Z,Go G,Min HK.Multifunctional nanorobot systems for active therapeutic delivery and synergistic chemo-photothermal therapy..Nano Lett2019;19:8550-64

[13] Dominguez S,Dobke M.Andronescu E.Nanotechnology to enhance transdermal delivery of hydrophilic humectants for improved skin care: a model for therapeutic applications..Nanostructures for drug delivery.2017;AmsterdamElsevier919-39

[14] Sikora NC.Postmenopausal skin aging - exploring the significance of estrogen-gut microbiota axis..JJ Expt Derm2019;3:1-4

[15] Dobke M,Vargas F.Skin aging and beauty exploring the gut microbiota connection..J Aesthet Reconstr Surg2019;5:1-3

[16] Velmeshev D. Single-cell genomics in disease research and diagnostics. Clin Lab Manager 2019;4:18-21. Available from: https://www.clinicallab.com/single-cell-genomics-in-disease-research-and-diagnostics-351 [Last accessed on 10 Jan 2020]

[17] Kadoya K,Jiang LI,Chung R.Upregulation of extracellular matrix genes corroborates clinical efficacy of human fibroblast-derived growth factors in skin rejuvenation..J Drugs Dermatol2017;16:1190-6

[18] Cohen SR.Injectable tissue replacement and regeneration: anatomic fat grafting to restore decayed facial tissues..Plast Reconstr Surg Glob Open2019;7:e2293 PMCID:PMC6756675

[19] Park JY.Stem cell fat graft. In: Liposuction.2018;SingaporeSpringer253-74

[20] Dobke M.Allogeneic microvascular tissue graft restores healing capacity in recalcitrant cleft palate fistula: a case report..J Den Max Surg2019;2:164-70

[21] Raper V.Gene therapies are being brought to a wider audience..Genet Eng Biotechnol News2019;39:7-9

[22] Guyatt GH,Vist GE,Falck-Ytter Y.GRADE: an emerging consensus on rating quality of evidence and strength of recommendations..BMJ2008;336:924-6 PMCID:PMC2335261

[23] Leask F.Spotting ‘unproven’ stem cell therapies in the wild..Biotechniques2019;67:253-5