Skin collagen through the lifestages: importance for skin health and beauty

David M. Reilly , Jennifer Lozano

Plastic and Aesthetic Research ›› 2021, Vol. 8 ›› Issue (1) : 2

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Plastic and Aesthetic Research ›› 2021, Vol. 8 ›› Issue (1) :2 DOI: 10.20517/2347-9264.2020.153
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Skin collagen through the lifestages: importance for skin health and beauty
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Abstract

Collagen-based supplements have become a keystone in the management of the ageing process, with proven ability to repair skin damage, bestowing a youthful and healthy appearance sought in the pursuit of beauty. Collagen is an essential scaffold protein that gives smoothness and elasticity to skin, but its production declines with age. Finding ways to tackle this problem is now strongly promoted as an effective way to transform skin and hair, repairing age-related deterioration. A growing number of scientific studies show exciting evidence that it is possible to rejuvenate ageing or damaged skin, improve function of worn joints, and support personal wellbeing and vitality. In recent times, research on the mechanisms which impact the production of collagen in skin and the ideal organization into functional fibres which give skin its characteristic elasticity and firmness has provided new insights into how this bio-scaffold can support cells, tissues and organs. The factors which influence collagen production over a lifetime (e.g., puberty, pregnancy, menopause, andropause), intrinsic factors (e.g., genetics, age, ethnicity) and extrinsic factors (e.g., UV-radiation, pollution, smoking) and the potential for new technologies, ingredients and devices to restore collagen and matrix components to their optimal condition are improving the ability to deliver anti-aging strategies with unprecedented results. This paper will review skin collagen production, structure and function throughout the lifestages, emphasizing its relationship with health, appearance and beauty.

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Collagen / health / beauty / ageing / skin

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David M. Reilly, Jennifer Lozano. Skin collagen through the lifestages: importance for skin health and beauty. Plastic and Aesthetic Research, 2021, 8(1): 2 DOI:10.20517/2347-9264.2020.153

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References

[1]

Fleischmajer R,Timpl R.Collagen fibrillogenesis in human skin..Ann N Y Acad Sci1985;460:246-57

[2]

Sibilla S,Brewer S,Licia G.An overview of the beneficial effects of hydrolysed collagen as a nutraceutical on skin properties: scientific background and clinical studies..Open Nutraceuticals J2015;8:29-42

[3]

Nolte SV,Rennekampff HO.Diversity of fibroblasts-a review on implications for skin tissue engineering..Cells Tissues Organs2008;187:165-76

[4]

Sherratt MJ.Tissue elasticity and the ageing elastic fibre..Age (Dordr)2009;31:305-25 PMCID:PMC2813052

[5]

Weihermann AC,Brohem CA.Elastin structure and its involvement in skin photoageing..Int J Cosmet Sci2017;39:241-7

[6]

Waller JM.Age and skin structure and function, a quantitative approach (II): protein, glycosaminoglycan, water, and lipid content and structure..Skin Res Technol2006;12:145-54

[7]

Bell E,Merrill C.Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro..Proc Natl Acad Sci U S A1979;76:1274-8 PMCID:PMC383233

[8]

Ogawa R.Mechanobiological dysregulation of the epidermis and dermis in skin disorders and in degeneration..J Cell Mol Med2013;17:817-22 PMCID:PMC3822886

[9]

Tracy LE,Caterson EJ.Extracellular matrix and dermal fibroblast function in the healing wound..Adv Wound Care (New Rochelle)2016;5:119-36 PMCID:PMC4779293

[10]

Song H.Beneficial effects of collagen hydrolysate: a review on recent developments..2017;1:1-4

[11]

Genovese L.Farage MA,Maibach H.Innovative nutraceutical approaches to counteract the signs of aging..Textbook of Aging Skin.2015;Berlin HeidelbergSpringer-Verlag1-25

[12]

Sikora E,Topolska K.The sources of natural antioxidants..Acta Sci Pol Technol Aliment2008;7:5-17

[13]

Tobin DJ.Introduction to skin aging..J Tissue Viability2017;26:37-46

[14]

Oikarinen A.The aging of skin: chronoaging versus photoaging..Photodermatol Photoimmunol Photomed1990;7:3-4

[15]

Knuutinen A,Risteli J.Smoking affects collagen synthesis and extracellular matrix turnover in human skin..Br J Dermatol2002;146:588-94

[16]

Edgar S,Genovese L,Laight D.Effects of collagen-derived bioactive peptides and natural antioxidant compounds on proliferation and matrix protein synthesis by cultured normal human dermal fibroblasts..Sci Rep2018;8:10474 PMCID:PMC6041269

[17]

Fligiel SE,Datta SC,Fisher GJ.Collagen degradation in aged/photodamaged skin in vivo and after exposure to matrix metalloproteinase-1 in vitro..J Invest Dermatol2003;120:842-8

[18]

Naylor EC,Sherratt MJ.Molecular aspects of skin ageing..Maturitas2011;69:249-56

[19]

Shoulders MD.Collagen structure and stability..Annu Rev Biochem2009;78:929-58 PMCID:PMC2846778

[20]

Kadler KE,Bella J.Collagens at a glance..J Cell Sci2007;120:1955-8

[21]

Vuorio E.The family of collagen genes..Annu Rev Biochem1990;59:837-72

[22]

Persikov AV,Brodsky B.Prediction of collagen stability from amino acid sequence..J Biol Chem2005;280:19343-9

[23]

Engel J.The zipper-like folding of collagen triple helices and the effects of mutations that disrupt the zipper..Annu Rev Biophys Biophys Chem1991;20:137-52

[24]

Bolboaca SD.Amino acids sequence analysis on collagen..Bulletin Usa Samv-cn2007;63-4:311-6

[25]

Eyre DR,Gallop PM.Cross-linking in collagen and elastin..Annu Rev Biochem1984;53:717-48

[26]

Buehler MJ.Nature designs tough collagen: explaining the nanostructure of collagen fibrils..Proc Natl Acad Sci U S A2006;103:12285-90 PMCID:PMC1567872

[27]

Kadler KE,Trotter JA.Collagen fibril formation..Biochem J1996;316:1-11 PMCID:PMC1217307

[28]

Gelse K,Aigner T.Collagens-structure, function, and biosynthesis..Adv Drug Deliv Rev2003;55:1531-46

[29]

Munakata H,Majima M.Interaction between collagens and glycosaminoglycans investigated using a surface plasmon resonance biosensor..Glycobiology1999;9:1023-7

[30]

Shin JE,Kim YK,Chung JH.Transcriptional regulation of proteoglycans and glycosaminoglycan chain-synthesizing glycosyltransferases by UV irradiation in cultured human dermal fibroblasts..J Korean Med Sci2011;26:417-24 PMCID:PMC3051091

[31]

Longo C,Beretti F,Pellacani G.Skin aging: in vivo microscopic assessment of epidermal and dermal changes by means of confocal microscopy..J Am Acad Dermatol2013;68:e73-82

[32]

Wurm EM,Curchin C,Prow TW.In vivo assessment of chronological ageing and photoageing in forearm skin using reflectance confocal microscopy..Br J Dermatol2012;167:270-9

[33]

Ueda M,Murata T.Combined multiphoton imaging and biaxial tissue extension for quantitative analysis of geometric fiber organization in human reticular dermis..Sci Rep2019;9:10644 PMCID:PMC6650477

[34]

Smith LT,Madri JA.Collagen types I, III, and V in human embryonic and fetal skin..Am J Anat1986;175:507-21

[35]

Anttinen H,Kivirikko KI.Age-related changes in human skin collagen galactosyltransferase and collagen glucosyltransferase activities..Clin Chim Acta1977;76:95-101

[36]

Ryazanov AG.Protein turnover plays a key role in aging..Mech Ageing Dev2002;123:207-13

[37]

Fisher GJ,Purohit T.Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin..Am J Pathol2009;174:101-14 PMCID:PMC2631323

[38]

Lovell CR,Duance VC,Young S.Type I and III collagen content and fibre distribution in normal human skin during ageing..Br J Dermatol1987;117:419-28

[39]

Fleischmajer R,Perlish JS,Fisher LW.Dermal collagen fibrils are hybrids of type I and type III collagen molecules..J Struct Biol1990;105:162-9

[40]

Verzijl N,Thorpe SR.Effect of collagen turnover on the accumulation of advanced glycation end products..J Biol Chem2000;275:39027-31

[41]

Pittayapruek P,Prapapan O,Ohtsuki M.Role of matrix metalloproteinases in photoaging and photocarcinogenesis..Int J Mol Sci2016;17:868 PMCID:PMC4926402

[42]

Lauer-Fields JL,Fields GB.Matrix metalloproteinases and collagen catabolism..Biopolymers2002;66:19-32

[43]

El-Domyati M,Saleh F.Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin..Exp Dermatol2002;11:398-405

[44]

Fisher GJ,Datta SC,Kang S.Pathophysiology of premature skin aging induced by ultraviolet light..N Engl J Med1997;337:1419-28

[45]

Sibilla S.Godfrey M.Current understanding of the effects of diet on skin health..Losing weight simply and safely.2014;FlorenceOfficina Editorale Oltrarno241-68

[46]

Varani J,Rittie L.Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation..Am J Pathol2006;168:1861-8 PMCID:PMC1606623

[47]

Chung JH,Choi HR.Modulation of skin collagen metabolism in aged and photoaged human skin in vivo..J Invest Dermatol2001;117:1218-24

[48]

Knutsen-Larson S,Dunnick CA.Acne vulgaris: pathogenesis, treatment, and needs assessment..Dermatol Clin2012;30:99-106viii-ix

[49]

Barnes LE,Fleischer AB.Quality of life measures for acne patients..Dermatol Clin2012;30:293-300ix

[50]

Hall G.Estrogen and skin: the effects of estrogen, menopause, and hormone replacement therapy on the skin..J Am Acad Dermatol2005;53:555-68quiz 569-72

[51]

Pappas A.The relationship of diet and acne: a review..Dermatoendocrinol2009;1:262-7 PMCID:PMC2836431

[52]

Jerajani HR,Li J,Marmor MJ.The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial..Indian J Dermatol Venereol Leprol2010;76:20-6

[53]

Capodice JL.Feasibility, tolerability, safety and efficacy of a pantothenic acid based dietary supplement in subjects with mild to moderate facial acne blemishes..J Cosmet, Dermatol Sci Appl2012;2:132-5

[54]

Yang M,Hatcher V.A randomized, double-blind, placebo-controlled study of a novel pantothenic Acid-based dietary supplement in subjects with mild to moderate facial acne..Dermatol Ther (Heidelb)2014;4:93-101 PMCID:PMC4065280

[55]

Lim SK,Lee YH.Comparison of vitamin D levels in patients with and without acne: a case-control study combined with a randomized controlled trial..PLoS One2016;11:e0161162 PMCID:PMC4999291

[56]

Read CP,Ruscheinsky MA,Mahendroo MS.Cervical remodeling during pregnancy and parturition: molecular characterization of the softening phase in mice..Reproduction2007;134:327-40

[57]

Torres J,Callejas A.Histobiomechanical remodeling of the cervix during pregnancy: proposed framework..Math Probl Eng2019;2019:1-11

[58]

Shuster S.The cause of striae distensae..Acta Derm Venereol Suppl (Stockh)1979;59:161-9

[59]

Albright F,Richardson AM.Postmenopausal osteoporosis: its clinical features..J Am Med Assoc1941;116:2465-74

[60]

Stevenson S.Effect of estrogens on skin aging and the potential role of SERMs..Clin Interv Aging2007;2:283-97 PMCID:PMC2685269

[61]

Thornton MJ.Estrogens and aging skin..Dermatoendocrinol2013;5:264-70 PMCID:PMC3772914

[62]

Verdier-Sévrain S,Gilchrest B.Biology of estrogens in skin: implications for skin aging..Exp Dermatol2006;15:83-94

[63]

Brincat M,Studd JW,de Trafford J.A study of the decrease of skin collagen content, skin thickness, and bone mass in the postmenopausal woman..Obstet Gynecol1987;70:840-5

[64]

Brincat MP,Galea R.Estrogens and the skin..Climacteric2005;8:110-23

[65]

Castelo-Branco C,González-Merlo J.Skin collagen changes related to age and hormone replacement therapy..Maturitas1992;15:113-9

[66]

Brincat M,Moniz CF,de Trafford J.Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy..Obstet Gynecol1987;70:123-7

[67]

Crisafulli A,Bitto A.Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study..Menopause2004;11:400-4

[68]

Fritsch H,Bitsche M,Reich O.Development of epithelial and mesenchymal regionalization of the human fetal utero-vaginal anlagen..J Anat2013;222:462-72 PMCID:PMC3610038

[69]

Kotsopoulos D,Liang YL,Teede HJ.The effects of soy protein containing phytoestrogens on menopausal symptoms in postmenopausal women..Climacteric2000;3:161-7

[70]

Kandola K,Birch-Machin MA.Oxidative stress-a key emerging impact factor in health, ageing, lifestyle and aesthetics..Int J Cosmet Sci.2015;37 Suppl 2:1-8

[71]

Lee J,Min DB.Reactive oxygen species, aging, and antioxidative nutraceuticals..Compr Rev Food Sci Food Saf2004;3:21-33

[72]

Wu D.Alcohol, oxidative stress, and free radical damage..Alcohol Res Health2003;27:277-84 PMCID:PMC6668865

[73]

Tyrrell RM.Ultraviolet radiation and free radical damage to skin..Biochem Soc Symp1995;61:47-53

[74]

Javle M.The role of PARP in DNA repair and its therapeutic exploitation..Br J Cancer2011;105:1114-22 PMCID:PMC3208503

[75]

Webster NR.Molecular structure of free radicals and their importance in biological reactions..Br J Anaesth1988;60:98-108

[76]

Jocelyn PC.Biochemistry of the SH group: the occurrence, chemical properties, metabolism and biological function of thiols and disulphides. In Oxidation of Thiols.1972;LondonAcademic Press94-115

[77]

Tu Y.Oxidative stress and human skin connective tissue aging..Cosmetics2016;3:28

[78]

Warren JJ.Tuning of the thermochemical and kinetic properties of ascorbate by its local environment: solution chemistry and biochemical implications..J Am Chem Soc2010;132:7784-93

[79]

Traber MG.Vitamins C and E: beneficial effects from a mechanistic perspective..Free Radic Biol Med2011;51:1000-13 PMCID:PMC3156342

[80]

Carlsen MH,Holte K.The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide..Nutr J2010;9:3 PMCID:PMC2841576

[81]

Ganceviciene R,Theodoridis A,Zouboulis CC.Skin anti-aging strategies..Dermatoendocrinol2012;4:308-19 PMCID:PMC3583892

[82]

Rowe JW.Successful aging..Gerontologist1997;37:433-40

[83]

Holstein MB.Self, society, and the “new gerontology”..Gerontologist2003;43:787-96

[84]

Mak TN, Caldeira S. The role of nutrition in active and healthy ageing: for prevention and treatment of age-related diseases: evidence so far. Available from: https://publications.jrc.ec.europa.eu/repository/handle/JRC90454. [Last accessed on 26 Jul 2019]

[85]

Schagen SK,Makrantonaki E.Discovering the link between nutrition and skin aging..Dermatoendocrinol2012;4:298-307 PMCID:PMC3583891

[86]

Asserin J,Shioya T.The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials..J Cosmet Dermatol2015;14:291-301

[87]

Béguin A.A novel micronutrient supplement in skin aging: a randomized placebo-controlled double-blind study..J Cosmet Dermatol2005;4:277-84

[88]

Borumand M.A study to assess the effect on wrinkles of a nutritional supplement high dosage of hydrolysed collagen..Cosmeceuticals2014;3:93-6

[89]

Borumand M.Effects of a nutritional supplement containing collagen peptides on skin elasticity, hydration and wrinkles..J Med Nutr Nutraceut2015;4:47-53

[90]

Hexsel D,Schunck M,Camozzato FO.Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails..J Cosmet Dermatol2017;16:520-6

[91]

Kiela PR.Physiology of intestinal absorption and secretion..Best Pract Res Clin Gastroenterol2016;30:145-59 PMCID:PMC4956471

[92]

Daniel H.Molecular and integrative physiology of intestinal peptide transport..Annu Rev Physiol2004;66:361-84

[93]

Miner-Williams WM,Moughan PJ.Are intact peptides absorbed from the healthy gut in the adult human?.Nutr Res Rev2014;27:308-29

[94]

Goodman BE.Insights into digestion and absorption of major nutrients in humans..Adv Physiol Educ2010;34:44-53

[95]

Kleinnijenhuis AJ,Maathuis AJH.Non-targeted and targeted analysis of collagen hydrolysates during the course of digestion and absorption..Anal Bioanal Chem2020;412:973-82 PMCID:PMC7005076

[96]

Last JA.Collagen biosynthesis..Environ Health Perspect1984;55:169-77 PMCID:PMC1568368

[97]

Moore PB.The ribosome returned..J Biol2009;8:8 PMCID:PMC2656218

[98]

Albaugh VL,Barbul A.proline precursors and collagen synthesis: biochemical challenges of nutrient supplementation and wound healing..J Nutr2017;147:2011-7 PMCID:PMC5657141

[99]

Iwai K,Taguchi Y.Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates..J Agric Food Chem2005;53:6531-6

[100]

Ohara H,Ito K,Sato K.Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources..J Agric Food Chem2007;55:1532-5

[101]

Postlethwaite AE,Kang AH.Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides..Proc Natl Acad Sci U S A1978;75:871-5 PMCID:PMC411359

[102]

Ohara H,Matsumoto H.Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts..J Dermatol2010;37:330-8

[103]

Myllyharju J.Collagens, modifying enzymes and their mutations in humans, flies and worms..Trends Genet2004;20:33-43

[104]

Rappu P,Myllyharju J.Role of prolyl hydroxylation in the molecular interactions of collagens..Essays Biochem2019;63:325-35 PMCID:PMC6744578

[105]

Yamauchi M.Lysine post-translational modifications of collagen..Essays Biochem2012;52:113-33 PMCID:PMC3499978

[106]

Miller EJ.Piez K.Collagen Chemistry..Extracellular matrix biochemistry.1984;Elsevier41-78

[107]

Igarashi T,Nayar S.The appearance of human skin..Foundations and Trends in Computer Graphics and Vision.2007;3:1-95

[108]

Borumand M.Daily consumption of the collagen supplement Pure Gold Collagen® reduces visible signs of aging..Clin Interv Aging2014;9:1747-58 PMCID:PMC4206255

[109]

Genovese L,Sibilla S.An insight into the changes in skin texture and properties following dietary intervention with a nutricosmeceutical containing a blend of collagen bioactive peptides and antioxidants..Skin Pharmacol Physiol2017;30:146-58

[110]

Kosmadaki MG.The role of telomeres in skin aging/photoaging..Micron2004;35:155-9

[111]

Yin B.Telomere shortening in cultured human dermal fibroblasts is associated with acute photodamage induced by UVA irradiation..Postepy Dermatol Alergol2013;30:13-8 PMCID:PMC3834693

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