The microbiome and aging

Abstract

The microbiota changes as the host ages, but also the relationship between host and bacteria impacts host aging and life expectancy. Differences in the composition of certain bacterial species in the human gut and skin microbiome have been identified between the elderly and the young. In this sense, it has been suggested that the manipulation of the microbiota of older adults would be an innovative strategy in the prevention and treatment of age-related comorbidities.

Keywords

Microbiome / aging / skin aging / skin cancer / probiotics

References

[1] Morgan XC.Chapter 12: Human microbiome analysis.PLoS Comput Biol2012;8:e1002808 PMCID:PMC3531975

[2] Szabó K,Bolla BS,Bíró T.Factors shaping the composition of the cutaneous microbiota.Br J Dermatol2017;176:344-51

[3] Sanford JA.Functions of the skin microbiota in health and disease.Semin Immunol2013;25:370-7 PMCID:PMC4219649

[4] Rosenthal M,Aiello A,Foxman B.Skin microbiota: microbial community structure and its potential association with health and disease.Infect Genet Evol2011;11:839-48 PMCID:PMC3114449

[5] Grice EA.The skin microbiome.Nat Rev Microbiol2011;9:244-53 PMCID:PMC3535073

[6] Grice EA,Conlan S.Topographical and temporal diversity of the human skin microbiome.Science2009;324:1190-2 PMCID:PMC2805064

[7] Wilantho A,Srisuttiyakorn C,Somboonna N.Diversity of bacterial communities on the facial skin of different age-group Thai males.PeerJ2017;5:e4084 PMCID:PMC5701550

[8] Ying S,Chi L.The influence of age and gender on skin-associated microbial communities in urban and rural human populations.PLoS One2015;10:e0141842 PMCID:PMC4624872

[9] Costello EK,Dethlefsen L,Relman DA.The application of ecological theory toward an understanding of the human microbiome.Science2012;336:1255-62 PMCID:PMC4208626

[10] Dréno B,Berardesca E.Microbiome in healthy skin, update for dermatologists.J Eur Acad Dermatol Venereol2016;30:2038-47 PMCID:PMC6084363

[11] Weyrich LS,Farrer AG,Cooper AJ.The skin microbiome: Associations between altered microbial communities and disease.Australas J Dermatol2015;56:268-74

[12] Oh J,Park M,Segre JA.NISC Comparative Sequencing ProgramTemporal stability of the human skin microbiome.Cell2016;165:854-66 PMCID:PMC4860256

[13] Byrd AL,Segre JA.The human skin microbiome.Nat Rev Microbiol2018;16:143-55

[14] Lacey N,Powell FC.Demodex mites--commensals, parasites or mutualistic organisms?.Dermatology2011;222:128-30

[15] Stecher B.The role of microbiota in infectious disease.Trends Microbiol2008;16:107-14

[16] Yu Y,Beynet D,Friedman AJ.The role of the cutaneous microbiome in skin cancer: lessons learned from the gut.J Drugs Dermatol2015;14:461-5

[17] Russo E,Ringressi MN,Amedei A.The interplay between the microbiome and the adaptive immune response in cancer development.Therap Adv Gastroenterol2016;9:594-605 PMCID:PMC4913328

[18] Wu S,Albesiano E.A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses.Nat Med2009;15:1016-22 PMCID:PMC3034219

[19] Bana B.The microbiome and aging.Annu Rev Genet2019;53:239-61

[20] Maynard C.The gut microbiota and ageing.Subcell Biochem2018;90:351-71

[21] Biagi E,Candela M.Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians.PLoS One2010;5:e10667 PMCID:PMC2871786

[22] Claesson MJ,Conde S.Gut microbiota composition correlates with diet and health in the elderly.Nature2012;488:178-84

[23] Smith P,Popkes M.Regulation of life span by the gut microbiota in the short-lived African turquoise killifish.Elife2017;6:e27014 PMCID:PMC5566455

[24] Bonté F,Archambault JC.Skin changes during ageing.Subcell Biochem2019;91:249-80

[25] Wu L,Deligios M.Age-related variation of bacterial and fungal communities in different body habitats across the young, elderly, and centenarians in Sardinia.mSphere2020;5:e00558-19 PMCID:PMC7045387

[26] Zapata HJ.The microbiota and microbiome in aging: potential implications in health and age-related diseases.J Am Geriatr Soc2015;63:776-81 PMCID:PMC4406803

[27] Leung MHY,Bastien P.Changes of the human skin microbiota upon chronic exposure to polycyclic aromatic hydrocarbon pollutants.Microbiome2020;8:100 PMCID:PMC7320578

[28] Russell-Goldman E.The pathobiology of skin aging: new insights into an old dilemma.Am J Pathol2020;190:1356-69 PMCID:PMC7481755

[29] Prescott SL,Logan AC.The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming.World Allergy Organ J2017;10:29 PMCID:PMC5568566

[30] Costello EK,Hamady M,Gordon JI.Bacterial community variation in human body habitats across space and time.Science2009;326:1694-7 PMCID:PMC3602444

[31] Kim HJ,Myeong NR.Segregation of age-related skin microbiome characteristics by functionality.Sci Rep2019;9:16748 PMCID:PMC6856112

[32] Jugé R,Breugnot J.Shift in skin microbiota of Western European women across aging.J Appl Microbiol2018;125:907-16

[33] Shibagaki N,Clavaud C.Aging-related changes in the diversity of women's skin microbiomes associated with oral bacteria.Sci Rep2017;7:10567 PMCID:PMC5585242

[34] Li W,Yu P,Wu X.Nested PCR-denaturing gradient gel electrophoresis analysis of human skin microbial diversity with age.Microbiol Res2014;169:686-92

[35] Huang S,Carrieri AP.Human skin, oral, and gut microbiomes predict chronological age.mSystems2020;5:e00630-19 PMCID:PMC7018528

[36] Gueniche A,Philippe D.Lactobacillus paracasei CNCM I-2116 (ST11) inhibits substance P-induced skin inflammation and accelerates skin barrier function recovery in vitro.Eur J Dermatol2010;20:731-7

[37] Kober MM.The effect of probiotics on immune regulation, acne, and photoaging.Int J Womens Dermatol2015;1:85-9 PMCID:PMC5418745

[38] Patra V,Wolf P.Potential of skin microbiome, pro- and/or pre-biotics to affect local cutaneous responses to UV exposure.Nutrients2020;12:1795 PMCID:PMC7353315

[39] Marzio L, Cinque B, Cupelli F, De Simone C, Cifone MG, Giuliani M. Increase of skin-ceramide levels in aged subjects following a short-term topical application of bacterial sphingomyelinase from Streptococcus thermophilus.Int J Immunopathol Pharmacol2008;21:137-43

[40] Maguire M.The role of microbiota, and probiotics and prebiotics in skin health.Arch Dermatol Res2017;309:411-21

[41] Vollmer DL,Lephart ED.Enhancing skin health: by oral administration of natural compounds and minerals with implications to the dermal microbiome.Int J Mol Sci2018;19:3059 PMCID:PMC6213755

[42] Meunier M,Chapuis E.From stem cells protection to skin microbiota balance: orobanche rapum extract, a new natural strategy.J Cosmet Dermatol2019;18:1140-54 PMCID:PMC7379634

[43] Liebert A,Johnstone DM,Kiat H."Photobiomics": can light, including photobiomodulation, alter the microbiome?.Photobiomodul Photomed Laser Surg2019;37:681-93 PMCID:PMC6859693

[44] Yoshimoto S,Atarashi K.Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.Nature2013;499:97-101

[45] Arthur JC,Mühlbauer M.Intestinal inflammation targets cancer-inducing activity of the microbiota.Science2012;338:120-3 PMCID:PMC3645302

[46] Mrázek J,Kučerová P.Melanoma-related changes in skin microbiome.Folia Microbiol (Praha)2019;64:435-42

[47] Nakatsuji T,Butcher AM.A commensal strain of Staphylococcus epidermidis protects against skin neoplasia.Sci Adv2018;4:eaao4502 PMCID:PMC5834004

[48] Wang Z,Wu CC.Skin commensal bacteria Staphylococcus epidermidis promote survival of melanocytes bearing UVB-induced DNA damage, while bacteria Propionibacterium acnes inhibit survival of melanocytes by increasing apoptosis.Photodermatol Photoimmunol Photomed2018;34:405-14

[49] Tang Y,Jiang H,Nie D.G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer.Int J Cancer2011;128:847-56

[50] Archer SY,Shei A.p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells.Proc Natl Acad Sci U S A1998;95:6791-6 PMCID:PMC22637

[51] Salava A,Pereira P.Skin microbiome in melanomas and melanocytic nevi.Eur J Dermatol2016;26:49-55

[52] Wood DLA,Tan JM.A natural history of actinic keratosis and cutaneous squamous cell carcinoma microbiomes.mBio2018;9:e01432-18 PMCID:PMC6178618

[53] Madhusudhan N,Halwachs B.Molecular profiling of keratinocyte skin tumors links Staphylococcus aureus overabundance and increased human β-defensin-2 expression to growth promotion of squamous cell carcinoma.Cancers (Basel)2020;12:541 PMCID:PMC7139500

[54] Matson V,Bao R.The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients.Science2018;359:104-8 PMCID:PMC6707353