One anastomosis gastric bypass and esojejunostomy in rats: surgical techniques

Leila M’Harzi; Matthieu Bruzzi; Jean-Marc Chevallier; Richard Douard

doi:10.20517/2574-1225.2019.22

Mini-invasive Surgery ›› 2019, Vol. 3 ›› Issue (1) :27 DOI: 10.20517/2574-1225.2019.22

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One anastomosis gastric bypass and esojejunostomy in rats: surgical techniques

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Abstract

One anastomosis gastric bypass (OAGB) is a popular bariatric procedure, but controversies remain regarding biliary reflux and the potential risk of cancer. Esophagojejunostomy (EJ) in rats is a validated and reproducible model for the development of metaplasia [Barett’s esophagus (BE)] and esophageal adenocarcinoma (EA) with a minimal exposure of 12 to 20 weeks. We are analyzing the risks of BE and EA in an OAGB rat model and comparing these with the EJ rat model. The purpose of this study is to describe our OAGB and EJ techniques in rats that we used to evaluate biliary reflux and share our experience with scientists and the bariatric community. These operations are short and simple procedures with acceptable morbidity.

Keywords

Mini-gastric bypass / biliary reflux / cancer

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Leila M’Harzi, Matthieu Bruzzi, Jean-Marc Chevallier, Richard Douard. One anastomosis gastric bypass and esojejunostomy in rats: surgical techniques. Mini-invasive Surgery, 2019, 3(1): 27 DOI:10.20517/2574-1225.2019.22

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References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Deitel M.Letter to the editor: bariatric surgery worldwide 2013 reveals a rise in mini-gastric bypass..Obes Surg2015;25:2166-8

[2]	Mahawar KK,Carr WR,Schroeder N.Current status of mini-gastric bypass..J Minim Access Surg2016;12:305-10 PMCID:PMC5022508

[3]	Rutledge R.The mini-gastric bypass: experience with the first 1,274 cases..Obes Surg2001;11:276-80

[4]	Bruzzi M,Czernichow S.One-Anastomosis gastric bypass: why biliary reflux remains controversial?.Obes Surg2017;27:545-7

[5]	Bruzzi M,Gronnier C,Couvelard A.Long-term evaluation of biliary reflux after experimental one-anastomosis gastric bypass in rats..Obes Surg2017;27:1119-22

[6]	Greene CL,DeMeester TR.Rat reflux model of esophageal cancer and its implication in human disease.2015;262:910-24

[7]	Gronnier C,Piessen G,Bot J.Operatively induced chronic reflux in rats: a suitable model for studying esophageal carcinogenesis?.Surg2013;154:955-67

[8]	Quinn R.Comparing rat’s to human’s age: How old is my rat in people years?.Nutrition2005;21:775-7

[9]	Pritchett-Corning KR,Mulder GB.Principles of rodent surgery for the new surgeon..J Vis Exp2011; PMCID:PMC3376945

[10]	Cavin JB,Lebtahi R,Arapis K.Differences in alimentary glucose absorption and intestinal disposal of blood glucose after Roux-en-Y gastric bypass vs sleeve gastrectomy..Gastroenterology2016;150:454-64