Rational Design, Synthesis, and Biological Assessment of Potential Indole-Capped HDAC6 Inhibitors for Gastric Cancer Suppression

Ya Gao; Hai-Qian Nie; Hong-Min Liu; Xin-Hui Zhang; Li-Ying Ma

doi:10.1002/mco2.70158

MedComm ›› 2025, Vol. 6 ›› Issue (4) :e70158 DOI: 10.1002/mco2.70158

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Rational Design, Synthesis, and Biological Assessment of Potential Indole-Capped HDAC6 Inhibitors for Gastric Cancer Suppression

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Ya Gao, Hai-Qian Nie, Hong-Min Liu, Xin-Hui Zhang, Li-Ying Ma. Rational Design, Synthesis, and Biological Assessment of Potential Indole-Capped HDAC6 Inhibitors for Gastric Cancer Suppression. MedComm, 2025, 6(4): e70158 DOI:10.1002/mco2.70158

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References

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[1]	E. C. Smyth, M. Nilsson, H. I. Grabsch, N. C. van Grieken, and F. Lordick, “Gastric Cancer,” Lancet 396, no. 10251 (2020): 635-648.

[2]	X.-H. Zhang, H.-Q. Kang, Y.-Y. Tao, et al., “Identification of Novel 1,3-Diaryl-1,2,4-Triazole-Capped Histone Deacetylase 6 Inhibitors With Potential Anti-Gastric Cancer Activity,” European Journal of Medicinal Chemistry 218 (2021): 113392.

[3]	Y.-C. Zheng, H.-Q. Kang, B. Wang, et al., “Curriculum Vitae of HDAC6 in Solid Tumors,” International Journal of Biological Macromolecules 230 (2023): 123219.

[4]	B. G. Bitler, S. Wu, P. H. Park, et al., “ARID1A-Mutated Ovarian Cancers Depend on HDAC6 Activity,” Nature Cell Biology 19, no. 8 (2017): 962-973.

[5]	C. Sun, R. Mezzadra, and T. N. Schumacher, “Regulation and Function of the PD-L1 Checkpoint,” Immunity 48, no. 3 (2018): 434-452.

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