The mechanism of the hypothalamus-pituitary-endocrine axis in anxiety disorder

Abstract

Anxiety disorder is a common and serious mental disorder. At present, the pathogenesis of anxiety disorder includes hypothalamus-pituitary-adrenal (HPA) axis, neuroimmune, and brain-gut axis disorders, among others. This paper discusses the correlation between anxiety disorder and the hypothalamus-pituitary-endocrine axis and finds that immune inflammation can be used as a “bridge” between the hypothalamus-pituitary-endocrine axis and anxiety disorder.

Keywords

anxiety disorder / hypothalamus-pituitary-adrenal (HPA) axis / hypothalamus-pituitary-thyroid (HPT) axis / hypothalamus-pituitary-gonad (HPG) axis / immune inflammation