Chemoproteomics reveals the epoxidase enzyme for the biosynthesis of camptothecin in Ophiorrhiza pumila
Tong Zhang, Yan Wang, Shiwen Wu, Ernuo Tian, Chengshuai Yang, Zhihua Zhou, Xing Yan, Pingping Wang
Chemoproteomics reveals the epoxidase enzyme for the biosynthesis of camptothecin in Ophiorrhiza pumila
[1] |
Gao,L., Su,C., Du,X., Wang, R., Chen,S., Zhou,Y., Liu,C., Liu,X., Tian, R., Zhang,L., et al. (2020). FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis. Nat. Chem. 2: 620–628.
|
[2] |
Hao,X., Wang,C., Zhou,W., Ruan, Q., Xie,C., Yang,Y., Xiao,C., Cai,Y., Wang, J., Wang,Y., et al. (2023). OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila. J. Integr. Plant Biol. 6: 133–149.
|
[3] |
He,Q., Ma,D., Li,W., Xing, L., Zhang,H., Wang,Y., Du,C., Li,X., Jia, Z., Li,X., et al. (2023). High-quality Fagopyrum esculentum genome provides insights into the flavonoid accumulation among different tissues and self-incompatibility. J. Integr. Plant Biol. 65: 1423–1441.
|
[4] |
Kang,M., Fu,R., Zhang,P., Lou, S., Yang,X., Chen,Y., Ma,T., Zhang,Y., Xi, Z., and Liu,J. (2021). A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis. Nat. Commun. 12: 3531.
|
[5] |
Miettinen,K., Pollier, J., Buyst,D., Arendt,P., Csuk,R., Sommerwerk,S., Moses,T., Mertens, J., Sonawane,P.D., Pauwels,L., et al. (2021). The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis. Nat. Commun. 8: 14153.
|
[6] |
Pu,X., Wang,M., Chen,M., Lin, X., Lei,M., Zhang,J., Yang,S., Wang,H., Liao, J., Zhang,L., et al. (2023). Proteomics-guided mining and characterization of epoxidase involved in camptothecin biosynthesis from Camptotheca acuminata. ACS Chem. Biol. 18: 1772–1785.
|
[7] |
Rai,A., Hirakawa, H., Nakabayashi,R., Kikuchi,S., Hayashi, K., Rai,M., Tsugawa,H., Nakaya, T., Mori,T., Nagasaki,H., et al. (2021). Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis. Nat. Commun. 12: 405.
|
[8] |
Sadre,R., Magallanes-Lundback, M., Pradhan,S., Salim,V., Mesberg, A., Jones,A.D., and DellaPenna,D. (2016). Metabolite diversity in alkaloid biosynthesis: A multilane (Diastereomer) highway for camptothecin synthesis in Camptotheca acuminata. Plant Cell 28: 1926–1944.
|
[9] |
Seca,A., and Pinto, D. (2018). Plant secondary metabolites as anticancer agents: Successes in clinical trials and therapeutic application. Int. J. Mol. Sci. 19: 263.
|
[10] |
Zhou,Y., Li,W., You,W., Di, Z., Wang,M., Zhou,H., Yuan,S., Wong,K., and Xiao, Y. (2018). Discovery of Arabidopsis UGT73C1 as a steviol-catalyzing UDP-glycosyltransferase with chemical probes. Chem. Commun. 54: 7179–7182.
|
/
〈 | 〉 |