Recent progress in human embryology

Conflict of interest

Jacek Z. Kubiak is the Editor-in-Chief of this journal, but was not in any way involved in the editorial and peer-review process conducted for this paper, directly or indirectly. The author declared that he has no known competing financial interests or personal relationships that could have influenced the work reported in this paper.

References

[1] Witt E. Form-a matter of generation: the relation of generation, form, and function in the epigenetic theory of Caspar F. Wolff. Sci Context. 2008; 21(4): 649-664. doi: 10.1017/s0269889708001993

[2] Song J, Zhao R, Zhang Y, et al. 3D post-implantation co-culture of human embryo and endometrium. Cell Stem Cell. 2026; 33(1): 58-72.e7. doi: 10.1016/j.stem.2025.12.002

[3] Li Q, Yuan Y, Zhao W, et al. A 3D in vitro model for studying human implantation and implantation failure. Cell. 2026; 189(1): 70-86.e20. doi: 10.1016/j.cell.2025.10.026

[4] Molè MA, Elderkin S, Zorzan I, et al. Modeling human embryo implantation in vitro. Cell. 2026; 189(1): 87-105.e28. doi: 10.1016/j.cell.2025.10.027

[5] Shibata S, Endo S, Nagai LAE, et al. Modeling embryo-endometrial interface recapitulating human embryo implantation. Sci Adv. 2024; 10(8). doi: 10.1126/sciadv.adi4819

[6] De Santis R, Jutras-Dubé L, Bourdrel S, Rice E, Piccolo FM, Brivanlou AH. Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models. Cell Stem Cell. 2025; 32(11): 1691-1704.e6. doi: 10.1016/j.stem.2025.09.006

[7] Olawade DB, Teke J, Adeleye KK, Weerasinghe K, Maidoki M, Clement David-Olawade A. Artificial intelligence in in-vitro fertilization (IVF): A new era of precision and personalization in fertility treatments. J Gynecol Obstet Human Reprod. 2025; 54(3): 102903. doi: 10.1016/j.jogoh.2024.102903

[8] Shoham Z. Artificial intelligence in reproductive medicine: Transforming assisted reproductive technologies. J IVF-Worldwide. 2025; 3(2): 1-8. doi: 10.46989/001c.137620

[9] Knoers NVAM. Prenatal and preimplantation genetic testing for monogenic kidney disorders. Kidney Int. 2025; 107(2): 255-261. doi: 10.1016/j.kint.2024.06.031

[10] Liu X, Zhang Q, Cao K, et al. Preimplantation genetic testing for monogenic disorders (PGT-M) for monogenic nephropathy: A single-center retrospective cohort analysis. Clin Kidney J. 2024; 18(1): sfae356. doi: 10.1093/ckj/sfae356

[11] Ledford H, Chen E. NIH ends support for most human fetal-tissue research - dismaying some scientists. Nature. 2026. doi: 10.1038/d41586-026-00251-2

[12] Now is not the time to defund human fetal tissue research. Nature. 2026; 650(8100): 8. doi: 10.1038/d41586-026-00308-2