Objective: To explore the underlying causes of death among vaccinated COVID-19 patients. Methods: The medical record of COVID-19 patients admitted to the main COVID-19 referral center in southeast Iran from January to March 2022 was investigated. Then, risk factors for mortality were statistically assessed. Results: 92 patients were included, with 50 in infectious disease ward and 42 in ICU ward. In total, 37% of patients succumbed to COVID-19. The median age of those who died was 69.9 years. Dementia and genitourinary system-related diseases was associated with an increased risk of death [6.00 (95% CI: 1.14-31.66) and 4.93 (95% CI: 1.80-13.52)]. Furthermore, the elevated levels of white blood cells, neutrophils, lactate dehydrogenase, blood urea nitrogen, and creatinine were associated with an increased risk of death by 4.93 (95% CI: 1.82-13.36), 16.57 (95% CI: 2.10-131.31), 3.23 (95% CI: 1.15-9.03), 4.48 (95% CI: 1.78-11.31), and 4.27 (95% CI: 1.49-12.22), respectively. Conclusions: Despite receiving the SARS-CoV-2 vaccine, individuals who suffer from dementia and genitourinary system-related diseases are at risk of death with new strains of SARS-CoV-2 infection. Furthermore, the increase of white blood cell, neutrophils, lactate dehydrogenase, blood urea nitrogen, and creatinine in patients’ blood can be considered as warning indicators of disease progression and death.

Thirty-seven years have passed since the first K-1 resuscitation maneuver implementation next to both basic and advanced CPR failure and Prof. Inchauspe has consistently continued such unique research recovering impending death situation victims in the most varied scenarios. After a dozen publications on the issue –mostly in World Journal of Critical Care Medicine and Hainan University Medical Editorial in China, the number of rescues increased to more than 195 cases. Having been contacted by experts in Ayurvedic medicine from India, the authors made a comparative analysis between said K-1 Yongquan and the Talahridaya points, and realized that not only are they located at the very same place for stimulation, but they are also integrated in the Reconciliation Vessel, a new Marvelous meridian discovered by Prof. Inchauspe within the Ancient Chinese classics. The following paper will show a statistical analysis made by Prof. Inchauspe and Dr. Saidman about the possible future impact that would result from the inclusion of the aforementioned maneuver in life support protocols.

Rationale: Paraquat, a highly toxic bipyridyl herbicide lacking a specific antidote, poses severe risks upon ingestion. However, the diagnosis of paraquat poisoning is complicated by its nonspecific initial symptoms, particularly when a detailed exposure history is not provided. Patient’s Concern: A 33-year-old man inadvertently ingested an unknown liquid and presented to medical services a day later with complaints of ongoing nausea, vomiting, and diarrhea. The assessment revealed elevated serum creatinine, signaling acute kidney injury, initially thought due to gastroenteritis and dehydration. Diagnosis: Acute renal insufficiency due to paraquat poisoning. Interventions: The treatment involved fluid resuscitation and antibiotics, but his decline led to intensive care unit transfer. Subsequent chest computed tomography scans indicated lung changes indicative of paraquat poisoning. A detailed history review and comprehensive blood and urine toxicology screens confirmed the diagnosis. Subsequently, aggressive interventions such as hemoperfusion and continuous renal replacement therapy were initiated, yet there was a further decline in respiratory function, necessitating mechanical ventilation. The prognosis was poor, and ultimately, the family chose to withdraw care. Outcomes: The patient succumbed to his illness. Lessons: This case underscores the importance of promptly and accurately diagnosing paraquat poisoning, as its vague early signs can lead to diagnostic delays, crucial due to the condition’s rapid progression. Alertness to paraquat poisoning is essential in patients with sudden gastrointestinal and renal symptoms post-exposure. Additionally, it underscores the necessity for public health measures to avert paraquat ingestion and advance therapeutic approaches.

Rationale: Opioids, the class of drugs, frequently used for pain relief in acute pancreatitis are known to act as a dual-edged sword. They are capable of causing acute pancreatitis though very rare. Patient’s Concern: A 45-year-old male presented with complaints of acute onset, severe pain in the abdomen, radiating to the back. The symptoms were preceded by regular oral intake of opium. Diagnosis: Opioid-induced pancreatitis. Interventions: He was managed conservatively with non-opioid analgesic-acetaminophen 15 mg/kg every 6 hours along with intravenous Ringer’s lactate for 5 days. Outcomes: The patient was discharged in stable vitals. Lessons: Drug-induced pancreatitis, though a rare entity, must be dealt with a high degree of suspicion once the other common factors are ruled out. Thus, this case highlights the importance that opioids can act as a double-edged sword in the way that it is given for pain relief in patients suffering from pancreatitis and can also be the culprit in causing it.