Tyrosine phosphorylation and bacterial virulence

Abstract

Tyrosine kinases and phosphatases are enzymes that regulate many bacterial proteins involved in promoting infection. Tyrosine kinases work by tacking phosphate molecules onto specific amino acids, while phosphatases take them off. Sarah Whitmore and Richard Lamont of the University of Louisville in Kentucky, USA, have now reviewed the structure and function of these enzymes, which contribute to bacterial virulence, including that of Porphyromonas gingivalis and Streptococcus gordonii. They explain that tyrosine kinases help regulate the production of specialized sugars that bacteria use to interact with target cells; many bacterial phosphatases, however, actively sabotage host cell signaling processes. The authors conclude that future work will provide a better understanding of these important enzymes and should help guide development of more effective antibacterial drugs.

Keywords

oral biofilm / Porphyromonas gingivalis / Streptococcus / tyrosine phosphorylation / virulence

References

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