Interleukin-1β induces human cementoblasts to support osteoclastogenesis

Abstract

An investigation into the interaction between tooth root cells and an inflammatory protein sheds light on root degradation following injury. Osteoclast cells digest old bone to release nutrients and recycle bone tissues in a vital process called bone resorption. Cementum, the mineral substance covering tooth roots, is not usually resorbed, but injury to the tissues surrounding roots often triggers inflammation followed by root degradation. To understand this phenomenon better, Ruchanee Salingcarnboriboon Ampornaramveth at Chulalongkorn University in Bangkok, Thailand, and co-workers investigated whether cementum cells can promote the formation of osteoclasts. They found that when cementum cells were treated with interleukin 1 beta, an inflammatory protein expressed at high levels in tissues following injury, levels of another protein needed for osteoclast formation increased. This boosted osteoclast formation around roots, resulting in root resorption

Keywords

cementoblast / interleukin-1β / osteoclast / receptor activator of nuclear factor kappa-B ligand / tooth resorption

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