Dual roles of UFMylation on stalling fork stability
Yisui Xia, Wenpeng Liu, Huiqiang Lou
Dual roles of UFMylation on stalling fork stability
The mechanism governing the stabilization of the replication fork under replication stress is pivotal for maintaining genomic integrity and cellular viability. In this context, the safeguard factors BRCA1/2 and nucleases engage in a regulatory equilibrium, modulating the extent of nascent strand end resection—a process vital for replication fork stabilization under stress and for fork restart upon stress released. The recruitment dynamics of these nucleases, however, remain to be elucidated. Recent two independent studies by
DNA replication / Replication stress / Fork stability / Genome stability / Nuclease / Post-translational modifications
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Liu, W., Krishnamoorthy, A., Zhao, R., & Cortez, D. (2020). Two replication fork remodeling pathways generate nuclease substrates for distinct fork protection factors. Science Advances, 6. https://doi.org/10.1126/sciadv.abc3598.
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