Pathogenesis and preventive measures of environmentrelated cardiovascular disease in northern China

Yukai Cao, Xuejie Han, Xinbo Zhao, Jiuxu Kan, Yue Yuan, Yue Li

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PDF(353 KB)
Frigid Zone Medicine ›› 2022, Vol. 2 ›› Issue (3) : 140-148. DOI: 10.2478/fzm-2022-0021
REVIEW

Pathogenesis and preventive measures of environmentrelated cardiovascular disease in northern China

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Abstract

Cardiovascular diseases (CVDs) have been the top-ranked cause of human death in the world for years, according to the World Health Organization. Accumulating evidence from epidemiological data supports the view that the risk of CVDs is higher in northern China than in southern area. There is no doubt that living environment has become a crucial factor contributing to the occurrence and progression of CVDs in northern region. However, there have not been any clinical guidelines for the prevention strategy of environment-related CVDs, especially for cold exposure. Thus, there is an urgent need for better understanding of the clinical characteristics and underlying mechanisms of cold-induced CVDs in order to formulate and implement proper and effective measures for minimizing the risk of CVDs for people residing in low-temperature area. Cold exposure, air pollution, lack of sunlight and irrational diet are believed to be crucial factors responsible for environment-related CVDs, and preventive measures might be carried out accordingly to decrease the high risk of CVDs in northern China.

Keywords

cold environment / cardiovascular disease / northern China

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Yukai Cao, Xuejie Han, Xinbo Zhao, Jiuxu Kan, Yue Yuan, Yue Li. Pathogenesis and preventive measures of environmentrelated cardiovascular disease in northern China. Frigid Zone Medicine, 2022, 2(3): 140‒148 https://doi.org/10.2478/fzm-2022-0021

References

[[1]]
Duan B. Concise Review: Harnessing iPSC-derived Cells for Ischemic Heart Disease Treatment. J Transl Int Med, 2020; 8(1): 20-25.
[[2]]
Sun D, Wang J, Shao W, et al. Pathogenesis and Damage Targets of Hypertensive Kidney Injury. J Transl Int Med, 2020; 8(4): 205-209.
[[3]]
Redant S, Honoré P M, De Bels D. Fifty Shades of Central Venous Pressure in the Cardiorenal Syndrome. J Transl Int Med, 2020; 8(1): 1-2.
[[4]]
Li X, Wu C, Lu J, et al. Cardiovascular risk factors in China: a nationwide population-based cohort study. Lancet Public Health, 2020; 5(12): e672-e681.
[[5]]
Yufan L, Liu Y, Wu X Z, et al. Physiological adaptability and subjective feelings of male college students in South and North China in an acceptable cold environment. J Civil, Archi Environ Eng. Journal of Chongqing Jianzhu University, 2018; 40(04): 55-62. (Chinese)
[[6]]
Lewington S, Li L, Sherliker P, et al. Seasonal variation in blood pressure and its relationship with outdoor temperature in 10 diverse regions of China: the China Kadoorie Biobank. J Hypertens, 2012; 30(7): 1383-1391.
[[7]]
Xiong T, Chen P, Mu Y, et al. Association between ambient temperature and hypertensive disorders in pregnancy in China. Nat Commun, 2020; 11(1): 2925.
[[8]]
Li N, Cai L, Heizhati M, et al. Maternal exposure to cold spells during pregnancy is associated with higher blood pressure and hypertension in offspring later in life. J Clin Hypertens (Greenwich), 2020; 22(10): 1884-1891.
[[9]]
Cheng J, Bambrick H, Tong S, et al. Winter temperature and myocardial infarction in Brisbane, Australia: Spatial and temporal analyses. Sci Total Environ, 2020; 715: 136860.
[[10]]
Goggins W B, Chan E Y. A study of the short-term associations between hospital admissions and mortality from heart failure and meteorological variables in Hong Kong: Weather and heart failure in Hong Kong. Int J Cardiol, 2017; 228: 537-542.
[[11]]
Nguyen J L, Link M S, Luttmann-Gibson H, et al. Drier air, lower temperatures, and triggering of paroxysmal atrial fibrillation. Epidemiology, 2015; 26(3): 374-380.
[[12]]
Rivera-Caravaca J M, Roldán V, Vicente V, et al. Particulate Matter and Temperature: Increased Risk of Adverse Clinical Outcomes in Patients With Atrial Fibrillation. Mayo Clin Proc, 2020; 95(11): 2360-2369.
[[13]]
Park J, Middlekauff H R, Campese V M. Abnormal sympathetic reactivity to the cold pressor test in overweight humans. Am J Hypertens, 2012; 25(12): 1236-1241.
[[14]]
Okamoto-Mizuno K, Tsuzuki K, Mizuno K, et al. Effects of low ambient temperature on heart rate variability during sleep in humans. Eur J Appl Physiol, 2009; 105(2): 191-197.
[[15]]
Sun Z. Cardiovascular responses to cold exposure. Front Biosci (Elite Ed), 2010; 2: 495-503.
[[16]]
Zhang X, Zhang S, Wang C, et al. Effects of moderate strength cold air exposure on blood pressure and biochemical indicators among cardiovascular and cerebrovascular patients. Int J Environ Res Public Health, 2014; 11(3): 2472-2487.
[[17]]
Qingmei W, Hong G, Ye T. Cold exposure and hypertension. Chinese Journal of Hypertension, 2013; 21(01): 21-24. (Chinese)
[[18]]
Giorgini P, Di Giosia P, Petrarca M, et al. Climate changes and human health: a review of the effect of environmental stressors on cardiovascular diseases across epidemiology and biological mechanisms. Curr Pharm Des, 2017; 23(22): 3247-3261.
[[19]]
Chen K, Sun D, Qu S, et al. Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system. Clin Sci (Lond), 2019; 133(9): 1097-1113.
[[20]]
Liu C, Chaudhry M T, Zhao D, et al. Heat shock protein 70 protects the quail cecum against oxidant stress, inflammatory injury, and microbiota imbalance induced by cold stress. Poult Sci, 2019; 98(11): 5432-5445.
[[21]]
Liu H, Hua L, Liu Q, et al. Cold stimuli facilitate inflammatory responses through transient receptor potential melastatin 8 (TRPM8) in primary airway epithelial cells of asthmatic mice. Inflammation, 2018; 41(4): 1266-1275.
[[22]]
Nie Y, Yan Z, Yan W, et al. Cold exposure stimulates lipid metabolism, induces inflammatory response in the adipose tissue of mice and promotes the osteogenic differentiation of BMMSCs via the p 38 MAPK pathway in vitro. Int J Clin Exp Pathol, 2015; 8(9): 10875-10886.
[[23]]
Crosswhite P, Sun Z. Ribonucleic acid interference knockdown of interleukin 6 attenuates cold-induced hypertension. Hypertension, 2010; 55(6): 1484-1491.
[[24]]
Yu H, Zhou Y, Duan Y, et al. Tranilast treats cold-related hypertension by reducing the expression of NLRP3 inflammasome. Frigid Zone Medicine, 2021; 1(2): 95-101.
[[25]]
Huang Q, Fang Q, Hu Z. A P 4 medicine perspective of gut microbiota and prediabetes: systems analysis and personalized intervention. J Transl Int Med, 2020; 8(3): 119-130.
[[26]]
Worthmann A, John C, Rühlemann M C, et al. Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis. Nat Med, 2017; 23(7): 839-849.
[[27]]
Zhang S, Zhang Y, Ahsan M Z, et al. Atorvastatin attenuates coldinduced hypertension by preventing gut barrier injury. J Cardiovasc Pharmacol, 2019; 74(2): 143-151.
[[28]]
Zhang K, Kaufman R J. From endoplasmic-reticulum stress to the inflammatory response. Nature, 2008; 454(7203): 455-462.
[[29]]
Castro A F, Rebhun J F, Quilliam L A. Measuring ras-family gtp levels in vivo--running hot and cold. Methods, 2005; 37(2): 190-196.
[[30]]
Xue Y, Petrovic N, Cao R, et al. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab, 2009; 9(1): 99-109.
[[31]]
Hotamisligil G S. Endoplasmic reticulum stress and atherosclerosis. Nat Med, 2010; 16(4): 396-399.
[[32]]
Chen G F, Sun Z. Effects of chronic cold exposure on the endothelin system. J Appl Physiol(1985), 2006; 100(5): 1719-1726.
[[33]]
Rigatelli G, Zuin M, Ngo T T, et al. Intracoronary Cavitation as a cause of plaque rupture and thrombosis propagation in patients with acute myocardial infarction: a computational study. J Transl Int Med, 2019; 7(2): 69-75.
[[34]]
Rigatelli G, Zuin M, Fong A, et al. Left main stenting induced flow disturbances on ascending aorta and aortic arch. J Transl Int Med, 2019; 7(1): 22-28.
[[35]]
Peng X, Wei C, Li H Z, et al. NPS2390, a selective calcium-sensing receptor antagonist controls the phenotypic modulation of hypoxic human pulmonary arterial smooth muscle cells by regulating autophagy. J Transl Int Med, 2019; 7(2): 59-68.
[[36]]
Wang P, Zhang N, Wu B, et al. The role of mitochondria in vascular calcification. J Transl Int Med, 2020; 8(2): 80-90.
[[37]]
Cesaroni G, Forastiere F, Stafoggia M, et al. Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project. BMJ, 2014; 348: f7412.
[[38]]
Mustafic H, Jabre P, Caussin C, et al. Main air pollutants and myocardial infarction: a systematic review and meta-analysis. JAMA, 2012; 307(7): 713-721.
[[39]]
Nawrot T S, Perez L, Künzli N, et al. Public health importance of triggers of myocardial infarction: a comparative risk assessment. Lancet, 2011; 377(9767): 732-740.
[[40]]
Yin P, Brauer M, Cohen A, et al. Long-term fine particulate matter exposure and nonaccidental and cause-specific mortality in a large national cohort of chinese men. Environ Health Perspect, 2017; 125(11): 117002.
[[41]]
Shah A S, Langrish J P, Nair H, et al. Global association of air pollution and heart failure: a systematic review and meta-analysis. Lancet, 2013; 382(9897): 1039-1048.
[[42]]
Yang B Y, Qian Z, Howard S W, et al. Global association between ambient air pollution and blood pressure: A systematic review and metaanalysis. Environ Pollut, 2018; 235: 576-588.
[[43]]
Eze I C, Hemkens L G, Bucher H C, et al. Association between ambient air pollution and diabetes mellitus in Europe and North America: systematic review and meta-analysis. Environ Health Perspect, 2015; 123(5): 381-389.
[[44]]
Shao Q, Liu T, Korantzopoulos P, et al. Association between air pollution and development of atrial fibrillation: A meta-analysis of observational studies. Heart Lung, 2016; 45(6): 557-562.
[[45]]
Miller M R, Newby D E. Air pollution and cardiovascular disease: car sick. Cardiovasc Res, 2020; 116(2): 279-294.
[[46]]
Provost E B, Madhloum N, Int Panis L, et al. Carotid intima-media thickness, a marker of subclinical atherosclerosis, and particulate air pollution exposure: the meta-analytical evidence. PLoS One, 2015; 10(5): e0127014.
[[47]]
Hoffmann B, Moebus S, Möhlenkamp S, et al. Residential exposure to traffic is associated with coronary atherosclerosis. Circulation, 2007; 116(5): 489-496.
[[48]]
Rao X, Zhong J, Brook R D, et al. Effect of particulate matter air pollution on cardiovascular oxidative stress pathways. Antioxid Redox Signal, 2018; 28(9): 797-818.
[[49]]
Calderón-Garcidueñas L, Vojdani A, Blaurock-Busch E, et al. Air pollution and children: neural and tight junction antibodies and combustion metals, the role of barrier breakdown and brain immunity in neurodegeneration. J Alzheimers Dis, 2015; 43(3): 1039-1058.
[[50]]
Seaton A, MacNee W, Donaldson K, et al. Particulate air pollution and acute health effects. Lancet, 1995; 345(8943): 176-178.
[[51]]
Kodavanti U P. Stretching the stress boundary: Linking air pollution health effects to a neurohormonal stress response. Biochim Biophys Acta, 2016; 1860(12): 2880-2890.
[[52]]
Channell M M, Paffett M L, Devlin R B, et al. Circulating factors induce coronary endothelial cell activation following exposure to inhaled diesel exhaust and nitrogen dioxide in humans: evidence from a novel translational in vitro model. Toxicol Sci, 2012; 127(1): 179-186.
[[53]]
Miller M R. The role of oxidative stress in the cardiovascular actions of particulate air pollution. Biochem Soc Trans, 2014; 42(4): 1006-1011.
[[54]]
Fiordelisi A, Piscitelli P, Trimarco B, et al. The mechanisms of air pollution and particulate matter in cardiovascular diseases. Heart Fail Rev, 2017; 22(3): 337-347.
[[55]]
Bai N, Kido T, Suzuki H, et al. Changes in atherosclerotic plaques induced by inhalation of diesel exhaust. Atherosclerosis, 2011; 216(2): 299-306.
[[56]]
Miyata R, van Eeden S F. The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter. Toxicol Appl Pharmacol, 2011; 257(2): 209-226.
[[57]]
Kampfrath T, Maiseyeu A, Ying Z, et al. Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways. Circ Res, 2011; 108(6): 716-726.
[[58]]
Shoenfelt J, Mitkus R J, Zeisler R, et al. Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter. J Leukoc Biol, 2009; 86(2): 303-312.
[[59]]
Qian H, Zhang Y, Wu B, et al. Structure and function of HECT E 3 ubiquitin ligases and their role in oxidative stress. J Transl Int Med, 2020; 8(2): 71-79.
[[60]]
Dou R, Ng K, Giovannucci E L, et al. Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence. Br J Nutr, 2016; 115(9): 1643-1660.
[[61]]
Lee J H, Gadi R, Spertus J A, et al. Prevalence of vitamin D deficiency in patients with acute myocardial infarction. Am J Cardiol, 2011; 107(11): 1636-1638.
[[62]]
Siasos G, Tousoulis D, Oikonomou E, et al. Vitamin D3, D2 and arterial wall properties in coronary artery disease. Curr Pharm Des, 2014; 20(37): 5914-5918.
[[63]]
Giovannucci E, Liu Y, Hollis B W, et al. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med, 2008; 168(11): 1174-1180.
[[64]]
Kim D H, Sabour S, Sagar U N, et al. Prevalence of hypovitaminosis D in cardiovascular diseases (from the National Health and Nutrition Examination Survey 2001 to 2004). Am J Cardiol, 2008;102(11): 1540- 1544.
[[65]]
Rostand S G. Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension, 1997; 30(2 Pt 1): 150- 156.
[[66]]
Kokot F, Schmidt-Gayk H, Wiecek A, et al. Influence of ultraviolet irradiation on plasma vitamin D and calcitonin levels in humans. Kidney Int Suppl, 1989; 27: S143- S146.
[[67]]
Sugden A, Smith J, Pennisi E. The future of forests. Science, 2008; 320(5882): 1435.
[[68]]
Li Y C, Qiao G, Uskokovic M, et al. Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure. J Steroid Biochem Mol Biol, 2004; 89-90(1-5): 387-392.
[[69]]
Bhattacharya S K, Ahokas R A, Carbone L D, et al. Macro- and micronutrients in African-Americans with heart failure. Heart Fail Rev, 2006; 11(1): 45-55.
[[70]]
Kutuk O, Basaga H. Inflammation meets oxidation: NF-kappaB as a mediator of initial lesion development in atherosclerosis. Trends Mol Med, 2003; 9(12): 549-557.
[[71]]
Chen S, Swier V J, Boosani C S, et al. Vitamin D deficiency accelerates coronary artery disease progression in Swine. Arterioscler Thromb Vasc Biol, 2016; 36(8): 1651-1659.
[[72]]
Sun X, Icli B, Wara A K, et al. MicroRNA-181b regulates NF-κB mediated vascular inflammation. J Clin Invest, 2012; 122(6): 1973-1990.
[[73]]
Onai Y, Suzuki J, Maejima Y, et al. Inhibition of NF-{kappa} B improves left ventricular remodeling and cardiac dysfunction after myocardial infarction. Am J Physiol Heart Circ Physiol, 2007;292(1): H530- H538.
[[74]]
Chen S, Law C S, Grigsby C L, et al. Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation, 2011; 124(17): 1838-1847.
[[75]]
Nizami H L, Katare P, Prabhakar P, et al. Vitamin D deficiency in rats causes cardiac dysfunction by inducing myocardial insulin resistance. Mol Nutr Food Res, 2019; 63(17): e1900109.
[[76]]
Liu N, Su H, Zhang Y, et al. The protective effect of 1,25(OH)(2)D(3) against cardiac hypertrophy is mediated by the cyclin-dependent kinase inhibitor p21. Eur J Pharmacol, 2020; 888: 173510.
[[77]]
Zhang Q Y, Jiang C M, Sun C, et al. Hypovitaminosis D is associated with endothelial dysfunction in patients with non-dialysis chronic kidney disease. J Nephrol, 2015; 28(4): 471-476.
[[78]]
Napoli C, de Nigris F, Williams-Ignarro S, et al. Nitric oxide and atherosclerosis: an update. Nitric Oxide, 2006; 15(4): 265-279.
[[79]]
Legarth C, Grimm D, Wehland M, et al. The impact of Vitamin D in the treatment of essential hypertension. Int J Mol Sci, 2018; 19(2):455.
[[80]]
Andrukhova O, Slavic S, Zeitz U, et al. Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice. Mol Endocrinol, 2014; 28(1): 53-64.
[[81]]
Wong M S, Man R Y, Vanhoutte P M. Calcium-independent phospholipase A(2) plays a key role in the endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol, 2010; 298(4): H1260-H1266.
[[82]]
Bhatnagar A. Environmental determinants of cardiovascular disease. Circ Res, 2017; 121(2): 162-180.
[[83]]
Opländer C, Volkmar C M, Paunel-Görgülü A, et al. Whole body UVA irradiation lowers systemic blood pressure by release of nitric oxide from intracutaneous photolabile nitric oxide derivates. Circ Res, 2009; 105(10): 1031-1040.
[[84]]
Geldenhuys S, Hart P H, Endersby R, et al. Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D in mice fed a high-fat diet. Diabetes, 2014; 63(11): 3759-3769.
[[85]]
Muggeridge D J, Sculthorpe N, Grace F M, et al. Acute whole body UVA irradiation combined with nitrate ingestion enhances time trial performance in trained cyclists. Nitric Oxide, 2015; 48: 3-9.
[[86]]
Uberti F, Lattuada D, Morsanuto V, et al. Vitamin D protects human endothelial cells from oxidative stress through the autophagic and survival pathways. J Clin Endocrinol Metab, 2014; 99(4): 1367-1374.
[[87]]
Wang M, Huang Y, Song Y, et al. Study on environmental and lifestyle factors for the north-south differential of cardiovascular disease in China. Front Public Health, 2021; 9: 615152.
[[88]]
Liu S W, Cai Y, Zeng X Y, et al. Deaths and life expectancy losses attributable to diet high in sodium in China. Zhonghua Liu Xing Bing Xue Za Zhi, 2017; 38(8): 1022-1027.
[[89]]
Liu M, Li Y C, Liu S W, et al. Burden of disease attributable to highsodium diets in China, 2013. Zhonghua Yu Fang Yi Xue Za Zhi, 2016; 50(9): 759-763.
[[90]]
He F J, Li J, Macgregor G A. Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and metaanalysis of randomised trials. BMJ, 2013; 346: f1325.
[[91]]
Reynolds K, Gu D, Whelton P K, et al. Prevalence and risk factors of overweight and obesity in China. Obesity (Silver Spring), 2007; 15(1): 10-18.
[[92]]
Li Z, Luo B, Du L, et al. Familial clustering of overweight and obesity among schoolchildren in northern China. Int J Clin Exp Med, 2014; 7(12): 5778-5783.
[[93]]
Liu B, Chen G, Zhao R, et al. Temporal trends in the prevalence of metabolic syndrome among middle-aged and elderly adults from 2011 to 2015 in China: the China health and retirement longitudinal study (CHARLS). BMC Public Health, 2021; 21(1): 1045.
[[94]]
Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr, 2021; 21(1): 135.
[[95]]
Qiu M S, Wang X W, Yao Y, et al. Protocol of jidong women health cohort study: rationale, design, and baseline characteristics. Biomed Environ Sci, 2019; 32(2): 144-152.
[[96]]
Iimura O, Shimamoto K. Salt and hypertension: water-sodium handling in essential hypertension. Ann N Y Acad Sci, 1993; 676: 105- 121.
[[97]]
DuPont J J, Greaney J L, Wenner M M, et al. High dietary sodium intake impairs endothelium-dependent dilation in healthy salt-resistant humans. J Hypertens, 2013; 31(3): 530-536.
[[98]]
Safar M E, Thuilliez C, Richard V, et al. Pressure-independent contribution of sodium to large artery structure and function in hypertension. Cardiovasc Res, 2000; 46(2): 269-276.
[[99]]
Sanders P W. Vascular consequences of dietary salt intake. Am J Physiol Renal Physiol, 2009; 297(2): F237- F243.
[[100]]
Cheng X, Su H. Effects of climatic temperature stress on cardiovascular diseases. Eur J Intern Med, 2010; 21(3): 164-167.
[[101]]
McCullough L, Arora S. Diagnosis and treatment of hypothermia. Am Fam Physician, 2004; 70(12): 2325-2332.
[[102]]
Zhang J W, Zhang Y, Li Y. Effects and mechanisms of living environment on cardiovascular disease in northern China. J Clin Pathol Sci, 2021; 41(01): 190-194.
[[103]]
Howden-Chapman P, Matheson A, Crane J, et al. Effect of insulating existing houses on health inequality: cluster randomised study in the community. BMJ, 2007; 334(7591): 460.
[[104]]
Umishio W, Ikaga T, Kario K, et al. Cross-sectional analysis of the relationship between home blood pressure and indoor temperature in winter: a nationwide smart wellness housing survey in Japan. Hypertension, 2019; 74(4): 756-766.
[[105]]
Sun Z, Cade R, Zhang Z, et al. Angiotensinogen gene knockout delays and attenuates cold-induced hypertension. Hypertension, 2003; 41(2): 322-327.
[[106]]
Monacelli F, Aramini I, Odetti P. For debate: The August sun and the December snow. J Am Med Dir Assoc, 2010; 11(6): 449-452.
[[107]]
Preventing injuries associated with extreme cold. Int J Trauma Nurs, 2001; 7(1): 26-30.
[[108]]
Ebi K L, Semenza J C. Community-based adaptation to the health impacts of climate change. Am J Prev Med, 2008; 35(5): 501-507.
[[109]]
Cold exposure and winter mortality from ischaemic heart disease, cerebrovascular disease, respiratory disease, and all causes in warm and cold regions of Europe. Lancet, 1997; 349(9062): 1341-1346.
[[110]]
Zhang Y, Li L, Hua Y, et al. Cardiac-specific knockout of ET(A) receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction. J Mol Cell Biol, 2012; 4(2): 97-107.
[[111]]
Lu S, Xu D. Cold stress accentuates pressure overload-induced cardiac hypertrophy and contractile dysfunction: role of TRPV1/AMPKmediated autophagy. Biochem Biophys Res Commun, 2013; 442(1-2): 8-15.
[[112]]
Münzel T, Sørensen M, Gori T, et al. Environmental stressors and cardio-metabolic disease: part I-epidemiologic evidence supporting a role for noise and air pollution and effects of mitigation strategies. Eur Heart J, 2017; 38(8): 550-556.
[[113]]
Qin C, Lv J, Yu C, et al. Dietary patterns and cardiometabolic diseases in 0.5 million Chinese adults: a 10-year cohort study. Nutr J, 2021; 20(1): 74.
[[114]]
Kahleova H, Levin S, Barnard N D. Vegetarian dietary patterns and cardiovascular disease. Prog Cardiovasc Dis, 2018; 61(1): 54-61.
[[115]]
Roager H M, Vogt J K, Kristensen M, et al. Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial. Gut, 2019; 68(1): 83-93.
[[116]]
Qin C, Lv J, Guo Y, et al. Associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults. Heart, 2018; 104(21): 1756-1763.
[[117]]
Alissa E M, Ferns G A. Dietary fruits and vegetables and cardiovascular diseases risk. Crit Rev Food Sci Nutr, 2017; 57(9): 1950-1962.
[[118]]
Kargin D, Tomaino L, Serra-Majem L. Experimental outcomes of the mediterranean diet: lessons learned from the predimed randomized controlled trial. Nutrients, 2019; 11(12): 2991.
[[119]]
Wang J, Lin X, Bloomgarden Z T, et al. The Jiangnan diet, a healthy diet pattern for Chinese. J Diabetes, 2020; 12(5): 365-371.
[[120]]
D'Souza M S, Dong T A, Ragazzo G, et al. From fad to fact: evaluating the impact of emerging diets on the prevention of cardiovascular disease. Am J Med, 2020; 133(10): 1126-1134.
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