Frontiers in Biology >

2010 , Vol. 5 >Issue 2: 105 - 115

DOI: https://doi.org/10.1007/s11515-010-0021-x

Research articles

The replication and transcription activator (RTA) of Kaposi’s sarcoma-associated herpesvirus/human herpesvirus-8

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  • 1.Nebraska Center for Virology and School of Biological Sciences, 102C Morrison Life Sciences Research Center, 4240 Fair Street, East Campus, University of Nebraska-Lincoln, Lincoln, NE 68583, USA；Current address: National Institutes of Health, 33 North Drive, Bethesda, MD, 20892, USA; 2.Nebraska Center for Virology and School of Biological Sciences, 102C Morrison Life Sciences Research Center, 4240 Fair Street, East Campus, University of Nebraska-Lincoln, Lincoln, NE 68583, USA; 3.2010-07-07 15:01:00;

Published date: 01 Apr 2010

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Abstract

Kaposi’s sarcoma-associated herpesvirus (KSHV) is g-2 herpesvirus with latency and lytic replication stages in its life-cycle. The viral replication and transcription activator (RTA) is the key protein for triggering KSHV lytic gene expression and replication from latency. In this review, we will discuss the gene expression program in KSHV lytic replication and latency, the regulation of the RTA expression, the RTA protein and the mechanisms that RTA utilizes to transactivate its target genes. We will focus on the RTA-mediated transactivation mechanisms, including DNA-binding, interacting with cellular co-factors and promoting repressor degradation.

Key words： Kaposi’s sarcoma-associated herpesvirus (KSHV); replication and transcription activator (RTA); transactivation

Cite this article

Zhilong YANG, Charles WOOD . The replication and transcription activator (RTA) of Kaposi’s sarcoma-associated herpesvirus/human herpesvirus-8[J]. Frontiers in Biology, 2010 , 5(2) : 105 -115 . DOI: 10.1007/s11515-010-0021-x

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