Research articles

Regulation of virus-triggered type I interferon signaling by cellular and viral proteins

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  • 1.College of Life Sciences, Wuhan University, Wuhan 430072, China; 2.2010-03-15 9:36:38;

Published date: 01 Feb 2010

Abstract

Host pattern recognition receptors (PRRs) recognize invading viral pathogens and initiate a series of signaling cascades that lead to the expression of type I interferons (IFNs) and inflammatory cytokines. During the past decade, significant progresses have been made to characterize PRRs such as Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs) and elucidate the molecular mechanisms of TLR- and RLR-mediated signaling. To avoid excessive and harmful immune effects caused by over-activation of these signaling pathways, host cells adopt a number of strategies to regulate them. In addition, invading viruses also employ a variety of mechanisms to inhibit the production of type I IFNs, thereby evading the supervision and clearance by the host. In this review, we briefly summarize the TLR- and RLR-mediated type I IFN signaling and then focus on the mechanisms by which host cellular and viral components regulate the expression of type I IFNs.

Cite this article

Bo ZHONG, Yan-Yi WANG, Hong-Bing SHU . Regulation of virus-triggered type I interferon signaling by cellular and viral proteins[J]. Frontiers in Biology, 2010 , 5(1) : 12 -31 . DOI: 10.1007/s11515-010-0013-x

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