Frontiers in Biology >

2010 , Vol. 5 >Issue 1: 8 - 11

DOI: https://doi.org/10.1007/s11515-010-0003-z

Research articles

Epigenetic reprogramming: roads to pluripotency

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  • 1.State Key Laboratory of Reproductive Biology, Institute of Zoology, Beijing 100101, China；Graduate School, Chinese Academy of Sciences, Beijing 100049, China; 2.State Key Laboratory of Reproductive Biology, Institute of Zoology, Beijing 100101, China; 3.2010-03-15 9:36:17;

Published date: 01 Feb 2010

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Abstract

Epigenetic reprogramming provides valuable resources for customized pluripotent stem cells generation, which are thought to be important bases of future regenerative medicine. Here we review the commonly used methods for epigenetic reprogramming: somatic cell nuclear transfer, cell fusion, cell extract treatment, inducing pluripotency by defined molecules, and briefly discuss their advantages and limitations. Finally we propose that mechanisms underlying epigenetic reprogramming and safety evaluation platform will be future research directions.

Key words： Epigenetic reprogramming; pluripotency; regenerative medicine

Cite this article

Wei LI, Qi ZHOU . Epigenetic reprogramming: roads to pluripotency[J]. Frontiers in Biology, 2010 , 5(1) : 8 -11 . DOI: 10.1007/s11515-010-0003-z

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