Received date: 05 Feb 2012
Accepted date: 20 Mar 2012
Published date: 01 Apr 2013
Copyright
Epigenetic deregulation is intimately associated with the development of human diseases. Intensive studies are currently underway to clarify the mechanism for the sake of achieving ideal diagnostic and therapeutic goals. It has been demonstrated that enzymes with histone-modifying activities can also target non-histone proteins, with the underlying mechanism remaining obscure. In this review, we focus on a novel histone mimicry strategy that may be wildly adapted during the non-histone substrate recognition process. Its potential clinical implications are also discussed.
Key words： epigenetics; histone mimicry
Yiwei LIN , Binhua P. ZHOU . Histone mimics: digging down under[J]. Frontiers in Biology, 2013 , 8(2) : 228 -233 . DOI: 10.1007/s11515-012-1211-5
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