Received date: 20 Sep 2012
Accepted date: 23 Oct 2012
Published date: 01 Feb 2013
Copyright
Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points toward DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon multiple critical pathways in the developing and adult brain.
Key words： DISC1; schizophrenia; depression; genetics; neural pathways
Pippa A. THOMSON , Elise L.V. MALAVASI , Ellen GRÜNEWALD , Dinesh C. SOARES , Malgorzata BORKOWSKA , J. Kirsty MILLAR . DISC1 genetics, biology and psychiatric illness[J]. Frontiers in Biology, 2013 , 8(1) : 1 -31 . DOI: 10.1007/s11515-012-1254-7
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