Cellular responses to unsaturated fatty acids mediated by their sensor Ubxd8
Received date: 17 Jul 2012
Accepted date: 17 Aug 2012
Published date: 01 Oct 2012
Copyright
Fatty acids (FAs) are crucial nutrient for cell survival because they are required for synthesis of phospholipids in cellular membranes and for generation of energy. However, overaccumulation of FAs is toxic. In response to excessive FAs, cells are able to activate multiple reactions to prevent their overaccumulation. These reactions are mediated by Ubxd8, a cellular protein that specifically interacts with unsaturated but not saturated FAs. The selective interaction of Ubxd8 with unsaturated FAs may explain previous observations that only unsaturated but not saturated FAs are able to stimulate the regulatory reactions that prevent overaccumulation of FAs. Thus, understanding the mechanism through which Ubxd8 maintains cellular FA homeostasis may provide new insights into saturated FA-induced lipotoxicity.
Key words： review; fatty acids; triglycerides; Ubxd8; Insig-1; SREBP
Jin YE . Cellular responses to unsaturated fatty acids mediated by their sensor Ubxd8[J]. Frontiers in Biology, 2012 , 7(5) : 397 -403 . DOI: 10.1007/s11515-012-1247-6
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