Multifaceted roles of ASB proteins and its pathological significance

Abstract

BACKGROUND: Post-translational (PT) modification in cells regulates many intracellular events like signal transduction, transcription, cell cycle, protein quality control, apoptosis and cellular development. Ubiquitination is one of the PT modifications which functions as a marker for degradation of target proteins by the proteasome and as a regulatory mechanism for several signalling pathways. The ubiquitination mechanism requires multiple enzymes, including E1, E2, and E3 ligases. Among them, E3 ligases play a major role in recognizing target proteins and an essential feature of protein homeostatic mechanisms within the cell. Most of the ASB (ankyrin repeat SOCS box) proteins function as RING family of E3 ubiquitin ligases characterized by the presence of two conserved domains N-terminal ankyrin repeat and C-terminal SOCS box domain

METHODS and RESULTS: Current studies have shown that some ASBs function as important regulators of several signalling pathways. This review gives an overview of ASB proteins on numerous cellular processes such as insulin signalling, spermatogenesis, myogenesis and in cellular development. Including various pathological situations, such as cancer, primary open-angle glaucoma, and inflammation, indicating that ASBs has important functions in both normal and pathological development

CONCLUSIONS: This article provides a precise comprehensive focus on ASBs protein structure, its biological functions, and their pathological significance.

Key words： ankyrin repeat; SOCS box; E3 ligase; cancer; spermatogenesis; cellular development

Acknowledgements

The authors wish to greatly acknowledge VIT University. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sector. The authors wish to thank Navin Kumar B for his help in the manuscript proof reading.

Compliance with ethical standards

The authors declare no conflicts of interests and the project was funded by no third party. Humans/Animal research were not involved in any part of the research.

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