The discovery of the fat-regulating phosphatidic acid phosphatase gene
Received date: 19 Sep 2010
Accepted date: 25 Oct 2010
Published date: 01 Jun 2011
Copyright
Phosphatidic acid phosphatase is a fat-regulating enzyme that plays a major role in controlling the balance of phosphatidic acid (substrate) and diacylglycerol (product), which are lipid precursors used for the synthesis of membrane phospholipids and triacylglycerol. Phosphatidic acid is also a signaling molecule that triggers phospholipid synthesis gene expression, membrane expansion, secretion, and endocytosis. While this important enzyme has been known for several decades, its gene was only identified recently from yeast. This discovery showed the importance of phosphatidic acid phosphatase in lipid metabolism in yeast as well as in higher eukaryotes including humans.
Key words: phosphatidic acid phosphatase; yeast; lipin; phospholipid; triacylglycerol
George M. CARMAN . The discovery of the fat-regulating phosphatidic acid phosphatase gene[J]. Frontiers in Biology, 2011 , 6(3) : 172 -176 . DOI: 10.1007/s11515-011-0910-7
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