RESEARCH ARTICLE

Factor XIII Val34Leu polymorphism and risk of recurrent pregnancy loss in Iranian population: a case control study

  • Seyed Mehdi Sajjadi 1 ,
  • Abbas Khosravi 2 ,
  • Jalil Pakravesh 3 ,
  • Zahra-soheila Soheili 4 ,
  • Shahram Samiei 5 ,
  • Saeed Mohammadi 6 ,
  • Mohammad Ali Jalali far , 5,7
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  • 1. Cellular and Molecular Research Center of Birjand University of Medical Sciences, Biriand, Iran
  • 2. Department of Hematology, Tehran University of Allied Medical Sciences, Tehran, Iran
  • 3. Department of Obstetrics and Gynecology, Aban General Hospital, Tehran, Iran
  • 4. Cellular and Molecular Biology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
  • 5. Blood Transfusion Research center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
  • 6. Hematology Oncology and Stem Cell Translantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • 7. Health research institute, Research Center of Thalassemia & Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Received date: 09 Apr 2016

Accepted date: 05 Sep 2016

Published date: 26 Dec 2016

Copyright

2016 Higher Education Press and Springer-Verlag Berlin Heidelberg

Abstract

BACKGROUND: Recurrent pregnancy loss (RPL) is a heterogeneous condition and thrombophilias have been considered as a probable cause.

OBJECTIVE: The aim of this study was to investigate the prevalence of the coagulation factor XIII Val34Leu polymorphism among women with unexplained RPL.

METHODS: A total of 140 women with a history of unexplained RPL and 100 age-matched healthy fertile women were recruited. The presence of FXIII Val34Leu polymorphism among the cases and controls was investigated using PCR-RFLP method.

RESULTS: Genotype analyses of the subjects revealed that the patients had a significantly higher prevalence of V/L and L/L than the controls (P<0.05): 33.5% vs. 15%, and 9.2% vs. 2%, respectively.

CONCLUSION: These results indicate a significant association between FXIII Val34Leu polymorphism and unexplained RPL in the Iranian patient.

Cite this article

Seyed Mehdi Sajjadi , Abbas Khosravi , Jalil Pakravesh , Zahra-soheila Soheili , Shahram Samiei , Saeed Mohammadi , Mohammad Ali Jalali far . Factor XIII Val34Leu polymorphism and risk of recurrent pregnancy loss in Iranian population: a case control study[J]. Frontiers in Biology, 2016 , 11(6) : 471 -475 . DOI: 10.1007/s11515-016-1419-x

Acknowledgments

This work was financially supported by grant: (U-91011) from Vice-Chancellor for Research Affairs of Ahvaz Jundishapur University of Medical Sciences. We greatly appreciate the assistance provided by Dr. Zohre Sharifi of the coagulation center of Iranian blood transfusion organization. We also thank all the participants for their cooperation in the study.

Compliance with ethics guidelines

There is no conflict of interest.
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