Antibacterial effect of bestatin during periodontitis

Abstract

Periodontitis is a polymicrobial disease inciting inflammatory destruction of the tooth-supporting tissues, i.e., periodontium. The initiation of this infectious disease is ascribed to the formation of subgingival biofilms. These biofilms cause stimulation of myriad of chronic inflammatory reactions by the affected tissue. The Gram-negative anaerobe Porphyromonas gingivalis is commonly found as part of the microbiota of subgingival biofilms, and is involved in the occurrence of the disease. P. gingivalis possesses numerous virulence factors supporting its survival, regulating its communication with other species in the biofilm, degrading host tissues. Fusobacterium nucleatum is pivotal for formation of biofilm and promotes growth and invasion properties of P. gingivalis. Bestatin is an aminopeptide inhibitor, produced by actinomycetes. It possesses antibacterial properties against P. gingivalis and F. nucleatum. The following review focuses on action of bestatin on the mentioned bacteria.

Key words： bestatin; Porphyromonas gingivalis; Fusobacterium nucleatum; periodontitis; biofilm

Acknowledgements

The author would like to thank Mr. Salil Jain and Mrs. Parul Jain. It was a self-funded research and the author reports no conflict of interest.

Compliance with ethics guidelines

This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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