A power analysis for future clinical trials on the potential adverse effects of SSRIs on amygdala reactivity
Received date: 31 Jan 2016
Accepted date: 25 Apr 2016
Published date: 05 Jul 2016
Copyright
Treatment of adolescents with antidepressants may induce an increased risk for suicidality in this population. The activity of the amygdala during processing of emotional faces with functional Magnetic Resonance Imaging (fMRI) is a well-known measure of emotional dysregulation. Based upon data of our prematurely ended randomized clinical trial with fluoxetine (NTR3103) in anxious and or depressed girls (12–14 years of age) we calculated that with the found effect size of r = 0.66, compared to placebo, only 8 subjects are needed to demonstrate increased amygdala activity following 16 weeks of treatment with fluoxetine.
Key words: amygdala reactivity; SSRI; adverse effects; anxiety; depression
M. A. Bottelier , A. Schrantee , G. van Wingen , H. G. Ruhé , M. B. de Ruiter , L. Reneman . A power analysis for future clinical trials on the potential adverse effects of SSRIs on amygdala reactivity[J]. Frontiers in Biology, 2016 , 11(3) : 256 -259 . DOI: 10.1007/s11515-016-1402-6
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