Invulnerability of bromelain against oxidative degeneration and cholinergic deficits imposed by dichlorvos in mice brains

Bharti Chaudhary, Sonam Agarwal, Renu Bist

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Front. Biol. ›› 2018, Vol. 13 ›› Issue (1) : 56-62. DOI: 10.1007/s11515-018-1479-1
RESEARCH ARTICLE

Invulnerability of bromelain against oxidative degeneration and cholinergic deficits imposed by dichlorvos in mice brains

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Abstract

BACKGROUND: The present study elucidates the protective potential of bromelain against dichlorvos intoxication in mice brains. Dichlorvos induces the oxidative stress by disproportionating the balance between free radicals generation and their scavenging in neurons which leads to neuronal degeneration.

METHODS: In this study, mice were divided into four groups- group I (control), group II (dichlorvos treated), group III (bromelain treated) and group IV (exposed to both bromelain and dichlorvos both).

RESULTS: Dichlorvos treatment increased the levels of thiobarbituric acid reactive substances (TBARS) and protein carbonyl content (PCC) which indicate the increased oxidative stress. Meanwhile, brain endogenous antioxidants and cholinesterases level was decreased after dichlorvos exposure. Levels of TBARS and PCC decreased whereas cholinesterases level was recorded to be elevated after bromelain exposure.

CONCLUSION: Bromelain offered neuroprotection by decreasing oxidative stress and augmenting cholinesterases in mice brains. This study highlights the invulnerability of bromelain against oxidative and cholinergic deficits in mice brains.

Keywords

oxidative stress / dichlorvos / bromelain / neuroprotection / neurotransmitter

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Bharti Chaudhary, Sonam Agarwal, Renu Bist. Invulnerability of bromelain against oxidative degeneration and cholinergic deficits imposed by dichlorvos in mice brains. Front. Biol., 2018, 13(1): 56‒62 https://doi.org/10.1007/s11515-018-1479-1

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Acknowledgments

We thank Banasthali University and Department of Science and Technology (DST), India for providing the facilities for present investigation.

Compliance with ethics guidelines

Bharti Chaudhary, Sonam Agarwal and Renu Bist declare that they have no conflict of interest.

RIGHTS & PERMISSIONS

2018 Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature
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