Phosphodiesterase 4 inhibitors and drugs of abuse: current knowledge and therapeutic opportunities

Christopher M. Olsen, Qing-Song Liu

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Front. Biol. ›› 2016, Vol. 11 ›› Issue (5) : 376-386. DOI: 10.1007/s11515-016-1424-0
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Phosphodiesterase 4 inhibitors and drugs of abuse: current knowledge and therapeutic opportunities

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Abstract

BACKGROUND: Long-term exposure to drugs of abuse causes an upregulation of the cAMP-signaling pathway in the nucleus accumbens and other forebrain regions, this common neuroadaptation is thought to underlie aspects of drug tolerance and dependence. Phosphodiesterase 4 (PDE4) is an enzyme that the selective hydrolyzes intracellular cAMP. It is expressed in several brain regions that regulate the reinforcing effects of drugs of abuse.

OBJECTIVE: Here, we review the current knowledge about central nervous system (CNS) distribution of PDE4 isoforms and the effects of systemic and brain-region specific inhibition of PDE4 on behavioral models of drug addiction.

METHODS: A systematic literature search was performed using the Pubmed.

RESULTS: Using behavioral sensitization, conditioned place preference and drug self-administration as behavioral models, a large number of studies have shown that local or systemic administration of PDE4 inhibitors reduce drug intake and/or drug seeking for psychostimulants, alcohol, and opioids in rats or mice.

CONCLUSIONS: Preclinical studies suggest that PDE4 could be a therapeutic target for several classes of substance use disorder. We conclude by identifying opportunities for the development of subtype-selective PDE4 inhibitors that may reduce addiction liability and minimize the side effects that limit the clinical potential of non-selective PDE4 inhibitors. Several PDE4 inhibitors have been clinically approved for other diseases. There is a promising possibility to repurpose these PDE4 inhibitors for the treatment of drug addiction as they are safe and well-tolerated in patients.

Keywords

PDE4 / PDE4 inhibitors / VTA / nucleus accumbens / drug addiction

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Christopher M. Olsen, Qing-Song Liu. Phosphodiesterase 4 inhibitors and drugs of abuse: current knowledge and therapeutic opportunities. Front. Biol., 2016, 11(5): 376‒386 https://doi.org/10.1007/s11515-016-1424-0

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Acknowledgments

Work in the authors’ laboratories was supported by US NIH Grants DA035217 (QSL), MH101146 (QSL), DA039276 (CMO), and DA041212 (CMO). Research was also supported by the Medical College of Wisconsin Research and Education Initiative Fund, a component of the Advancing a Healthier Wisconsin Endowment at the Medical College of Wisconsin (CMO, QSL).

Compliance with ethics guidelines

Christopher M. Olsen and Qing-song Liu declare that they have no conflict of interest. This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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