Transgenic mouse models for studying adult neurogenesis

Abstract

The mammalian hippocampus shows a remarkable capacity for continued neurogenesis throughout life. Newborn neurons, generated by the radial neural stem cells (NSCs), are important for learning and memory as well as mood control. During aging, the number and responses of NSCs to neurogenic stimuli diminish, leading to decreased neurogenesis and age-associated cognitive decline and psychiatric disorders. Thus, adult hippocampal neurogenesis has garnered significant interest because targeting it could be a novel potential therapeutic strategy for these disorders. However, if we are to use neurogenesis to halt or reverse hippocampal-related pathology, we need to understand better the core molecular machinery that governs NSC and their progeny. In this review, we summarize a wide variety of mouse models used in adult neurogenesis field, present their advantages and disadvantages based on specificity and efficiency of labeling of different cell types, and review their contribution to our understanding of the biology and the heterogeneity of different cell types found in adult neurogenic niches.

Keywords

adult neurogenesis / mouse models / neural stem cells / neuroprogenitors / lineage tracing

References

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Acknowledgments

We thank the members of Maletic-Savatic laboratory for comments and critical reading of the paper. This project was supported by the Dana Foundation, the McKnight Endowment for Science, the CPRIT grant (RP130573CPRIT), and the Nancy Chang Award for Research Excellence (M.M.S.). The research was also supported in part by the Baylor College of Medicine Microscopy Core (P30HD024064 Intellectual and Developmental Disabilities Research Grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.‚‚

Compliance with ethics guidelines

Fatih Semerci and Mirjana Maletić-Savatić declare no conflicts of interest.

This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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