Metabolomics in Schizophrenia and Major Depressive Disorder

Abstract

Defining pathophenotype, a systems level consequence of a disease genotype, together with environmental and stochastic influences, is an arduous task in psychiatry. It is also an appealing goal, given growing need for appreciation of brain disorders biological complexity, aspiration for diagnostic tests development and ambition to identify novel drug targets. Here, we focus on the Schizophrenia and Major Depressive Disorder and highlight recent advances in metabolomics research. As a systems biology tool, metabolomics holds a promise to take part in elucidating interactions between genes and environment, in complex behavioral traits and psychopathology risk translational research.

Keywords

Schizophrenia / Major Depressive Disorder / omics / metabolomics / systems biology

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Acknowledgements

This work was supported by Brain and Behavior Research Foundation 2012 Young Investigator Award (19722) to Dr. S. Milanovic.

Compliance with ethics guidelines

Iva Petrovchich, Alexandra Sosinsky, Anish Konde4, Abigail Archibald, David Henderson, Mirjana Maletic-Savatic and Snezana Milanovic declare that they have no conflict of interest. This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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2016 Higher Education Press and Springer-Verlag Berlin Heidelberg