Polyhydroxyalkanoates: Current applications in the medical field

Iftikhar Ali, Nazia Jamil

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Front. Biol. ›› 2016, Vol. 11 ›› Issue (1) : 19-27. DOI: 10.1007/s11515-016-1389-z
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Polyhydroxyalkanoates: Current applications in the medical field

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Abstract

Polyhydroxyalkanoates (PHAs) are a class of biopolyesters that are synthesized intracellularly by microorganisms, mainly by different genera of eubacteria. These biopolymers have diverse physical and chemical properties that also classify them as biodegradable in nature and make them compatible to living systems. In the last two decades or so, PHAs have emerged as potential useful materials in the medical field for different applications owing to their unique properties. The lower acidity and bioactivity of PHAs confer them with minimal risk compared to other biopolymers such as poly-lactic acid (PLA) and poly-glycolic acid (PGA). Therefore, the versatility of PHAs in terms of their non-toxic degradation products, biocompatibility, desired surface modifications, wide range of physical and chemical properties, cellular growth support, and attachment without carcinogenic effects have enabled their use as in vivo implants such as sutures, adhesion barriers, and valves to guide tissue repair and in regeneration devices such as cardiovascular patches, articular cartilage repair scaffolds, bone graft substitutes, and nerve guides. Here, we briefly describe some of the most recent innovative research involving the use of PHAs in medical applications. Microbial production of PHAs also provides the opportunity to develop PHAs with more unique monomer compositions economically through metabolic engineering approaches. At present, it is generally established that the PHA monomer composition and surface modifications influence cell responses.PHA synthesis by bacteria does not require the use of a catalyst (used in the synthesis of other polymers), which further promotes the biocompatibility of PHA-derived polymers.

Keywords

Biopolymers / polyhydroxyalkanoates / biocompatibility / medical implantations

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Iftikhar Ali, Nazia Jamil. Polyhydroxyalkanoates: Current applications in the medical field. Front. Biol., 2016, 11(1): 19‒27 https://doi.org/10.1007/s11515-016-1389-z

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Acknowledgement

The authors are grateful to the University of the Punjab, Pakistan and the Higher Education Commission, Pakistan for support of this study..
The authors declare no conflict of interest.
Both authors conceived of the work and agreed on the manuscript contents. The literature review and main manuscript writing were performed by Iftikhar Ali

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