Development of glutamatergic innervation during maturation of adult-born neurons

Abstract

The dentate gyrus is the entrance of the hippocampal formation and a primary target of excitatory afferents from the entorhinal cortex that carry spatial and sensory information. Mounting evidence suggests that continual adult neurogenesis contributes to appropriate processing of cortical information. The ongoing integration of adult born neurons dynamically modulates connectivity of the network, potentially contributing to dentate cognitive function. Here we review the current understanding of how glutamatergic innervation develops during the progression of adult-born neuron maturation. Summarizing the developmental stages of dentate neurogenesis, we also demonstrate that new neurons at an immature stage of maturation begin to process afferent activity from both medial and lateral entorhinal cortices.

Keywords

dentate gyrus / adult neurogenesis / glutamatergic innervation / granule cell / neuroprogenitor

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Acknowledgements

We thank Ryan Vaden and Jose Carlos Gonzalez for critical reading of this manuscript. LOW is funded by NIH (R01NS064025).

Cristina V. Dieni, Adam J. Wieckert and Linda Overstreet-Wadiche declare that they have no conflict of interest. All animal procedures followed the Guide for the Care and Use of Laboratory Animals, US Public Health Service, and were approved by the University of Alabama at Birmingham Institutional Animal Care and Use Committee.

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