Emerging roles of autophagy in metabolism and metabolic disorders

Altea Rocchi, Congcong He

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Front. Biol. ›› 2015, Vol. 10 ›› Issue (2) : 154-164. DOI: 10.1007/s11515-015-1354-2
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Emerging roles of autophagy in metabolism and metabolic disorders

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Abstract

The global prevalence of metabolic disorders is an immediate threat to human health. Genetic features, environmental aspects and lifestyle changes are the major risk factors determining metabolic dysfunction in the body. Autophagy is a housekeeping stress-induced lysosomal degradation pathway, which recycles macromolecules and metabolites for new protein synthesis and energy production and regulates cellular homeostasis by clearance of damaged protein or organelles. Recently, a dramatically increasing number of literatures has shown that defects of the autophagic machinery is associated with dysfunction of multiple metabolic tissues including pancreatic β cells, liver, adipose tissue and muscle, and is implicated in metabolic disorders such as obesity and insulin resistance. Here in this review, we summarize the representative works on these topics and discuss the versatile roles of autophagy in the regulation of cellular metabolism and its possible implication in metabolic diseases.

Keywords

autophagy / selective autophagy / metabolism / metabolic disease / obesity / diabetes

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Altea Rocchi, Congcong He. Emerging roles of autophagy in metabolism and metabolic disorders. Front. Biol., 2015, 10(2): 154‒164 https://doi.org/10.1007/s11515-015-1354-2

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Acknowledgements

This work was supported by the NIH Pathway to Independence Award R00 DK094980 to C.H.
Altea Rocchi and Congcong He declare that they have no conflict of interest. This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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2014 Higher Education Press and Springer-Verlag Berlin Heidelberg
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