Current trends of antibiotic resistance in clinical isolates of Staphylococcus aureus

Kapil Dev SHARMA, Rajendra Prasad SAINI, Loganathan KARTHIK

PDF(128 KB)
PDF(128 KB)
Front. Biol. ›› 2014, Vol. 9 ›› Issue (4) : 287-290. DOI: 10.1007/s11515-014-1317-z
RESEARCH ARTICLE
RESEARCH ARTICLE

Current trends of antibiotic resistance in clinical isolates of Staphylococcus aureus

Author information +
History +

Abstract

Staphyloccus aureus (S. aureus) is a well known human pathogen known to causes a verity of infections in humans. In recent years S. aureus is reported to show drug resistant toward commonly known drugs. Therefore, this study was designed to study the pattern of antibiotic resistance in 50 clinical isolates of S. aureus isolated at Dhanwantri Hospital and Research Centre, Jaipur, Rajasthan, India. S. aureus cultures were isolated from different clinical samples, pus, throat swabs and urine on Blood agar and MacConkey agar and Chrom agar plats and characterized by an array of microscopic and biochemical tests. Antibiotic sensitivity test was performed by standard disc diffusion method (Kirby bayer's method) on Muller Hinton agar plates. During this study, among 50  S. aureus isolates 48 (96%) were found to be resistance toward Aztreonam and Doxicycline followed by Ciprofloxacin (n = 45, 90%), Cefpodoxime and Ceftazidime (n = 44, 88%), Cefuroxime (n = 40, 80%), Pipracillin+ Tazobactum (n = 38, 76%), Cefoparazone (n = 36, 72%), Amoxicillin+ Clavulanic acid and Ceftriaxone (n = 33, 66%), Levofloxacin (n = 32, 64%), Moxifloxacin (n = 31, 62%), Ofloaxacin (n = 25, 50%), Cloxacillin (n = 22, 44%), Azithromycin (n = 21, 42%), Clindamycin (n = 19, 38%), Meropenem (n = 18, 36%), Clarithromycin (n = 16, 32%), Ampicillin+ sulbactam (n = 13, 26%), Amikacin (n = 12, 24%), Impipenem (n = 8, 16%), Linezolid and Methicillin (n = 7, 14%) and Teicoplanin (n = 3, 6%). In conclusion, the isolated S. aureus found to be resistant toward common antibiotics, however all isolates were found to be susceptible to Vancomycin.

Graphical abstract

Keywords

Staphyloccus aureus / infections / antibiotic resistance

Cite this article

Download citation ▾
Kapil Dev SHARMA, Rajendra Prasad SAINI, Loganathan KARTHIK. Current trends of antibiotic resistance in clinical isolates of Staphylococcus aureus. Front. Biol., 2014, 9(4): 287‒290 https://doi.org/10.1007/s11515-014-1317-z

References

[1]
Appelbaum P C (2006). MRSA—the tip of the iceberg. Clin Microbiol Infect, 12(s2 Suppl 2): 3−10
CrossRef Pubmed Google scholar
[2]
Bal A M, Gould I M (2005). Antibiotic resistance in Staphylococcus aureus and its relevance in therapy. Expert Opin Pharmacother, 6(13): 2257−2269
CrossRef Pubmed Google scholar
[3]
Bamberger D M, Boyd S E (2005). Management of Staphylococcus aureus infections. Am Fam Physician, 72(12): 2474−2481
Pubmed
[4]
Chambers H F (2001). The changing epidemiology of Staphylococcus aureus? Emerg Infect Dis, 7(2): 178−182
CrossRef Pubmed Google scholar
[5]
Iqbal M, Ali K M, Daraz B, Siddique U (2004). Bacteriology of mastitic milk and in vitro antibiogram of the isolates. Pakistan Vet. J, 24: 161−164
[6]
Livermore D M (2000). Antibiotic resistance in staphylococci. Int J Antimicrob Agents, 16(Suppl 1): S3−S10
CrossRef Pubmed Google scholar
[7]
Lowy F D (2003). Antimicrobial resistance: the example of Staphylococcus aureus. J Clin Invest, 111(9): 1265−1273
CrossRef Pubmed Google scholar
[8]
Pantosti A, Sanchini A, Monaco M (2007). Mechanisms of antibiotic resistance in Staphylococcus aureus. Future Microbiol, 2(3): 323−334
CrossRef Pubmed Google scholar
[9]
Rayner C, Munckhof W J (2005). Antibiotics currently used in the treatment of infections caused by Staphylococcus aureus. Intern Med J, 35(s2 Suppl 2): S3−S16
CrossRef Pubmed Google scholar
[10]
WHO (1999). Leading cause of death.

Acknowledgments

The authors wish to thank management of Dhanwantri Hospital and Research Centre, Jaipur, Rajasthan, India and Shri JJT University, Jhunjhunu, Rajasthan, India for providing necessary facilities and support for the completion of this work.
Compliance with ethics guidelines
Kapil Dev Sharma, Rajendra Prasad Saini, Loganathan Karthik declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects performed by any of the authors.

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg
PDF(128 KB)

Accesses

Citations

Detail

Sections
Recommended

/