The perinucleolar compartment associates with malignancy

Abstract

The perinucleolar compartment (PNC) is a unique nuclear substructure, forming predominantly in cancer cells both in vitro and in vivo. PNC prevalence (percentage of cells containing at least one PNC) has been found to positively correlate with disease progression in several cancers (breast, ovarian, and colon). While there is a clear association between PNCs and cancer, the molecular function of the PNC remains unclear. Here we summarize the current understanding of the association of PNCs with cancer and its possible functions in cancer cells.

Keywords

PNC / cancer / nuclear substructure / gene expression regulation / structure and function

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Acknowledgements

We thank the support from NIH grant (2R01GM078555-05) and from the Robert H. Lurie Comprehensive Cancer Center.

Compliance with ethics guidelines

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2014 Higher Education Press and Springer-Verlag Berlin Heidelberg