Notch signaling and its emerging role in autoimmunity

Abstract

Studies of notch signaling in immune cells have uncovered critical roles for this pathway both during the differentiation and effector function phases of immune responses. Cells of the myeloid lineage, including macrophages and dendritic cells, function as key components of innate immune defense against infection and, by acting as antigen presenting cells, can instruct cells of the adaptive immune response, specifically CD4 and CD8 T cells. Tight regulation of this functional interaction is needed to ensure a well-balanced immune response and its dysregulation may indirectly or directly cause the tissue damage characteristic of autoimmune diseases. In this review, the focus will be placed on those recent findings which support a role for notch signaling in inflammatory responses mediated by macrophages and other myeloid lineage cells, as well as peripheral T cells, and their relevance to inflammatory and autoimmne diseases.

Keywords

notch signaling / inflammation / autoimmunity

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Acknowledgments

We gratefully acknowledge the efforts of those researchers whose work has expanded our understanding of the complicated role notch signaling plays in inflammation and autoimmunity and we apologize to those authors whose findings could not be included due to space limitations. TP is supported in part by the Special Task Force for Activating Research (STAR) from the Centenary Academic Development Project, Chulalongkorn University and by the Thailand Research Fund (TRF), Grant No. RSA5280014. LMM is supported in part by grants from the American Heart Association, the Charles H. Hood Foundation for Child Health Research and the Aplastic Anemia and MDS International Foundation.

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2014 Higher Education Press and Springer-Verlag Berlin Heidelberg