ATP-dependent chromatin remodeling complex SWI/SNF in cardiogenesis and cardiac progenitor cell development
Ienglam LEI, Mai Har SHAM, Zhong WANG
ATP-dependent chromatin remodeling complex SWI/SNF in cardiogenesis and cardiac progenitor cell development
The recent identification of cardiac progenitor cells (CPCs) provides a new paradigm for studying and treating heart disease. To realize the full potential of CPCs for therapeutic purposes, it is essential to understand the genetic and epigenetic mechanisms guiding CPC differentiation into cardiomyocytes, smooth muscle, or endothelial cells. ATP-dependent chromatin remodelers mediate one critical epigenetic mechanism. These large multiprotein complexes open up chromatin to modulate transcription factor access to DNA. SWI/SNF, one of the major types of chromatin remodelers, plays a key role in various aspects of development (
ATP-dependent chromatin remodeling / SWI/SNF / cardiogenesis and cardiac progenitor cell
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