Study on immunity of dengue virus and dengue vaccine development

Abstract

In the study of vaccines for dengue viruses, which are multivalent immunization, genetically and antigenically distinct, we should have more sophisticated understanding of viral immune physiology. Because the immune response to dengue and its role in the pathophysiology of dengue fever and dengue hemorrhagic fever are multifaceted, several different efforts have been made to engineer a protective vaccine. Because of space limitations, this review is focused only on vaccines that have emerged from preclinical studies into clinical trial.

Keywords

dengue fever / immunology / T cells / vaccines

References

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2014 Higher Education Press and Springer-Verlag Berlin Heidelberg