封面图片
2016年, 第10卷 第3期
(Dae Hwan Shin, Yu Tong Tam, Glen S. Kwon, pp. 348-359)
Several amphiphilic block copolymers (ABCs) have been widely studied for drug solubilization that enables safe intravenous administration of anticancer drugs, including PEG-b-PLA, PEG-b-poly(propylene glycol)-b-PEG (i.e., Pluronics®), PEG-b-poly(ε-caprolactone) (PEG-b-PCL) and PEG-b-poly(α-amino acid). Proven safety of ABCs is paramount for intravenous administration, along with other major requirements that include sterility, stability, solubility and scale-up. ABCs tend to disrupt cellular membranes less than low molecular weight surfactants, such as Cremophor EL, and undergo renal clearance that limits accumulation in the body, increasing safety. While the primary driving force for drug solubilization is hydrophobic interaction, polarity and hydrogen bonding play parts in governing interaction between drug and core region of polymeric micelles. Thus, structural diversity of core-forming blocks of ABCs permits drug solubilization of a variety of poorly water-soluble anticancer agents; for example, camptothecin, paclitaxel, resveratrol and valspodar, increasing water solubility by 103-fold.
[展开] ...
ISSN 2095-0179 (Print)
ISSN 2095-0187 (Online)
CN 11-5981/TQ
Postal Subscription Code 80-969 Formerly Known as Frontiers of Chemical Science and Engineering in China 2018 Impact Factor: 2.809