Photo-affinity labeling strategy to study the binding site of G protein-coupled receptors

Abstract

G protein-coupled receptors (GPCRs) are involved in the control of every aspect of our behavior and physiology. GPCR can be involved in pathological processes as well and are linked to numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. This article reviews the methods of approaching photo-affinity labeling strategy to obtain the possible G protein-coupled receptors’s binding site.

Keywords

GPCR / photo-affinity / labeling / rhodopsin / transmembrane / structure / binding

References

[1] Gloriam, D. E.; Fredriksson, R.; Schiöth, H. B., BMC Genomics2007, 8, 338-405

[2] Ruiz-Gómez, G.; Tyndall, J. D. A.; Pfeiffer, B.; Abbenante, G.; Fairlie, D. P.Chem. Rev.2010, 110, PR1-PR41

[3] Smit, M. J.; Vischer, H. F.; Bakker, R. A.; Jongejan, A.; Timmerman, H.; Pardo, L.; Leurs, R., Annu. Rev. Pharmacol. Toxicol. 2007, 47, 53-87

[4] Scheer, A.; Cotecchia, S., J. Recept. Signal Transduct. Res. 1997, 17, 57-73

[5] Gether, U., Endocr. Rev.2000, 21, 90-113

[6] Fredriksson, R.; Lagerström, M. C.; Lundin, L. G.; Schiöth, H. B., Mol. Pharmacol.2003, 63, 1256-1272

[7] Bourne, H. R., Curr. Opin. Cell Biol. 1997, 9, 134-142

[8] Hamm, H. E., J. Biol. Chem. 1998, 273, 669-672

[9] Wess, J., FASEB J.1997, 11, 346-354

[10] Palczewski, K.; Kumasaka, T.; Hori, T.; Behnke, C. A.; Motoshima, H.; Fox, B. A.; Le Trong, I.; Teller, D. C.; Okada, T.; Stenkamp, R. E.; Yamamoto, M.; Miyano, M., Science2000, 289, 739-745

[11] Schwartz, T. W., Curr. Opin. Biotechnol. 1994, 5, 434-444

[12] Frimurer, T. M.; Ulven, T.; Elling, C. E.; Gerlach, L. O.; Kostenis, E.; Högberg, T., Bioorg. Med. Chem. Lett. 2005, 15, 3707-3712

[13] Choe, H. W.; Park, J. H.; Kim, Y. J.; Ernst, O. P., Neuropharmacology2011, 60, 52-57

[14] Eckford, P. D. W.; Sharom, F. J., Chem. Rev. 2009, 109, 2989-3011

[15] DasJ., Chemical Reviews2011, null-null.

[16] Chowdhry, V.; Westheimer, F. H., Annu. Rev. Biochem.1979, 48, 293-325

[17] Schuster, D. I.; Probst, W. C.; Ehrlich, G. K.; Singh, G., Photochem. Photobiol.1989, 49, 785-804

[18] Bayley, H.; Knowles, J. R., Methods Enzymol.1977, 46, 69-114

[19] Souto, M. L.; Um, J.; Borhan, B.; Nakanishi, K., Helv. Chim. Acta2000, 83, 2617-2628

[20] Mills, J. S.; Miettinen, H. M.; Barnidge, D.; Vlases, M. J.; Wimer-Mackin, S.; Dratz, E. A.; Sunner, J.; Jesaitis, A. J., J. Biol. Chem.1998, 273, 10428-10435

[21] Kisselev, O. G.; Meyer, C. K.; Heck, M.; Ernst, O. P.; Hofmann, K. P., Proc. Natl. Acad. Sci. U.S.A.1999, 96, 4898-4903

[22] Bubis, J.; Neitzel, J. J.; Saraswat, L. D.; Taylor, S. S., J. Biol. Chem.1988, 263, 9668-9673

[23] Cross, R. L.; Cunningham, D.; Miller, C. G.; Xue, Z. X.; Zhou, J. M.; Boyer, P. D., Proc. Natl. Acad. Sci. U.S.A.1987, 84, 5715-5719

[24] Garin, J.; Boulay, F.; Issartel, J. P.; Lunardi, J.; Vignais, P. V., Biochemistry1986, 25, 4431-4437

[25] Grammer, J. C.; Kuwayama, H.; Yount, R. G., Biochemistry1993, 32, 5725-5732

[26] Knight, K. L.; McEntee, K., J. Biol. Chem. 1985, 260, 185-191

[27] Mayinger, P.; Klingenberg, M., Biochemistry1992, 31, 10536-10543

[28] Shoemaker, M. T.; Haley, B. E., Biochemistry1993, 32, 1883-1890

[29] Winkler, E.; Klingenberg, M., Eur. J. Biochem. 1992, 203, 295-304

[30] Xue, Z. X.; Miller, C. G.; Zhou, J. M.; Boyer, P. D., FEBS Lett.1987, 223, 391-394

[31] Poe, R.; Grayzar, J.; Young, M. J. T.; Leyva, E.; Schnapp, K. A.; Platz, M. S., J. Am. Chem. Soc.1991, 113, 3209-3211

[32] Poe, R.; Schnapp, K.; Young, M. J. T.; Grayzar, J.; Platz, M. S., J. Am. Chem. Soc.1992, 114, 5054-5067

[33] Soundararajan, N.; Platz, M. S., J. Org. Chem.1990, 55, 2034-2044

[34] Young, M. J. T.; Platz, M. S., Tetrahedron Lett.1989, 30, 2199-2202

[35] Young, M. J. T.; Platz, M. S., J. Org. Chem.1991, 56, 6403-6406

[36] Bayley, H., Photogenerated Reagents in Biochemistry and Molecular Biology, Vol. 12,1983.

[37] Ando, W., Chem. Diazonium Diazo Groups1978, Part 1, 341-487.

[38] Brunner, J.; Senn, H.; Richards, F. M., J. Biol. Chem.1980, 255, 3313-3318

[39] TurroN. J., Modern Molecular Photochemistry, 1978

[40] Rando, R. R., Chem. Rev.2001, 101, 1881-1896

[41] Borhan, B.; Souto, M. L.; Imai, H.; Shichida, Y.; Nakanishi, K., Science2000, 288, 2209-2212

[42] Ernst, O. P.; Hofmann, K. P.; Sakmar, T. P., J. Biol. Chem.1995, 270, 10580-10586

[43] Ernst, O. P.; Meyer, C. K.; Marin, E. P.; Henklein, P.; Fu, W. Y.; Sakmar, T. P.; Hofmann, K. P., J. Biol. Chem.2000, 275, 1937-1943

[44] Franke, R. R.; Sakmar, T. P.; Graham, R. M.; Khorana, H. G., J. Biol. Chem.1992, 267, 14767-14774

[45] Hargrave, P. A.; McDowell, J. H., FASEB J.1992, 6, 2323-2331

[46] Nathans, J., Biochemistry1992, 31, 4923-4931

[47] Stryer, L., J. Biol. Chem.1991, 266, 10711-10714

[48] Palczewski, K.; Kumasaka, T.; Hori, T.; Behnke, C. A.; Motoshima, H.; Fox, B. A.; Le Trong, I.; Teller, D. C.; Okada, T.; Stenkamp, R. E.; Yamamoto, M.; Miyano, M., Science2000, 289, 739-745

[49] Hamm, H. E.; Deretic, D.; Arendt, A.; Hargrave, P. A.; Koenig, B.; Hofmann, K. P., Science1988, 241, 832-835

[50] Bohm, A.; Gaudet, R.; Sigler, P. B., Curr. Opin. Biotechnol.1997, 8, 480-487

[51] Helmreich, E. J. M.; Hofmann, K.P.Biochim. Biophys. Acta, Rev. Biomembr.1996, 1286, 285-322

[52] Sprang, S. R., Annu. Rev. Biochem.1997, 66, 639-678

[53] Marin, E. P.; Krishna, A. G.; Sakmar, T. P., Biochemistry2002, 41, 6988-6994

[54] Lambright, D. G.; Sondek, J.; Bohm, A.; Skiba, N. P.; Hamm, H. E.; Sigler, P. B., Nature1996, 379, 311-319

[55] Cai, K.; Itoh, Y.; Khorana, H. G., Proc. Natl. Acad. Sci. U.S.A.2001, 98, 4877-4882

[56] Kisselev, O. G.; Ermolaeva, M. V.; Gautam, N., J. Biol. Chem.1994, 269, 21399-21402

[57] Yasuda, H.; Lindorfer, M. A.; Woodfork, K. A.; Fletcher, J. E.; Garrison, J. C., J. Biol. Chem.1996, 271, 18588-18595

[58] Taylor, J. M.; Jacob-Mosier, G. G.; Lawton, R. G.; VanDort, M.; Neubig, R. R., J. Biol. Chem.1996, 271, 3336-3339

[59] Chen, Y.; Wu, Y.; Henklein, P.; Li, X.; Hofmann, K. P.; Nakanishi, K.; Ernst, O. P., Chemistry2010, 16, 7389-7394

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