Bioassay studies of cobalt (II) complexes of modified diamine

Abstract

Coordination compounds of modified diamine, the basic unit of which are ethylenediamine, with that of Co (II) are prepared. The modified diamines are ethylenediaceticacid (EDDA) and N,N,N,N-tetaraethylene-1,2-diamine (TEEDA). These diamines are characterized through ¹H-NMR, ¹³C-NMR, elemental analysis and IR techniques. Cobalt (II) complexes of these two ligands were prepared and characterized by physical measurements including elemental analysis, IR, UV-Visible, magnetic susceptibilities and conductance measurements. Antibacterial activities are also carried out in order to investigate the biological activity upon complexation. They were screened against four pathogenic bacteria like BoldItalic and BoldItalic. The results showed significant enhancement in activities.

Keywords

EDDA / TEEDA / cobalt complexes / antibacterial studies

References

[1] Louie, A. Y.; Meade, T. J., Chem. Rev.1999, 99, 2711–2734

[2] Scozzafava, A.; Menabuoni, L.; Mincione, F.; Mincione, G.; Supuran, C. T., Bioorg. Med. Chem. Lett.2001, 11, 575–582

[3] Scozzafava, A.; Supran, C. T., Bioorg. Med. Chem. Lett.2000, 43, 3577

[4] Williams, R. J. P., Bioinorganic Chemistry, American Chemical Society, Washington, 1971

[5] Brown, D. H.; Smith, W. E.; Teape, J. W.; Lewis, A. J., J. Med. Chem.1980, 23, 729–734

[6] Gillard, R. D., Inorganica Chimica Acta Reviews1961, 1, 60

[7] Walsh, C., Science2001, 409, 226

[8] Bertini, I.; Gray, H. B.; Lippard, S. J.; Valentine, J. S., Bioinorganic Chemistry, University Science Books, Mill Valley, 1994

[9] Kirchner, S.; Wei, Y. K.; Francis, D.; Bergman, J. G., J. Med. Chem.1966, 9, 369–372

[10] Hussain, M. S.Rehman, S. U., Zeitschrift Fur Naturforschung1978, 33b, 67

[11] Hussain, M. S.; Rehman, S. U., Inorg. Chim. Acta1982, 60, 233

[12] Sorenson, J. R. L., Inflammatory Diseases and Copper, Human Press, NJ, 1982

[13] Nagar, R.; Mohan, G., J. Inorg. Biochem.1991, 42, 9–16

[14] Oga, S.; Taniguchi, S. F.; Najjar, R.; Souza, A. R., J. Inorg. Biochem.1991, 41, 45–51

[15] Barboiu, M.; Cimpoisu, M.; Guran, C.; Supran, C. T., Metal based Drugs1996, 3, 227

[16] Hodgkin, D. G.; Pickworth, J.; Robertson, J. H.; Trueblood, K. N.; Prosen, R. J.; White, J. G., Nature1955, 176, 325–328

[17] Barker, H. A.; Rooze, V.; Suzuki, F.; Iodice, A. A., J. Biol. Chem.1964, 239, 3260–3266

[18] Cannata, J. J. B.; Focesi, A. Jr; Mazumder, R.; Warner, R. C.; Ochoa, S., J. Biol. Chem.1965, 240, 3249–3257

[19] Flavin, M.; Ochoa, S., J. Biol. Chem.1957, 229, 965–979

[20] Kaziro, Y.; Ochoa, S., Adv. Enzymol. Relat. Areas Mol. Biol.1964, 26, 283–378

[21] Abeles, R. H.; Lee, H. A. Jr, J. Biol. Chem.1961, 236, 2347–2350

[22] Babior, B. M., J. Biol. Chem.1969, 244, 2917–2926

[23] Abrams, R.; Duraiswami, S., Biochem. Biophys. Res. Commun.1965, 18, 409–414

[24] Burke, G. T.; Mangum, J. H.; Brodie, J. D., Biochemistry1970, 9, 4297–4302

[25] Wood, J. M.; Kennedy, F. S.; Wolfe, R. S., J. Biol. Chem.1968, 7, 1707

[26] Ghambeer, R. K.; Wood, H. G.; Schulman, M.; Ljungdahl, L., Arch. Biochem. Biophys.1971, 143, 471–484

[27] Rehman, S. U.; Noreen, S.; Rashida, M.; Ikram, K.; Ali, I.; Ahmad, M. A.; Bukhari, I. H., Nucleus2009, 46, 501–506

[28] Legg, J. I.; Averill, D. F.; Smith, D. L., Inorg. Chem.1972, 11, 2344–2349

[29] Omar, M. M.; Mohamed, G. G.; Ibrahim, A. A., Spectrochim. Acta A Mol. Biomol. Spectrosc.2009, 73, 358–369

[30] Musker, W. K.; Hussain, M. S., Inorg. Chem.1966, 5, 1416–1419

[31] Musker, W. K.; Hussain, M. S., Inorg. Chem.1969, 8, 528–536

[32] Vogel’s, A Text Book of Quantitative Inorganic Analysis, 4th Ed. London: ELBS and Longman, 1978

[33] Atta-ur-Rahman, Choudhary, M.I.; Thomsen, W. J., Bioassay Techniques for Drug Development. Amsterdam: Harwood Academic, 2001

[34] Nickolov, Zh.; Georgieva, G.; Stoilovab, D.; Ivanova, I., J. Mol. Struct.1995, 354, 119–125

Acknowledgements

We are grateful to HEJ Research Institute of Chemistry, University of Karachi, Pakistan, for providing us the facility of CHNS, the elemental analysis and we are also grateful to Chemistry Department of Quaid-i-Azam University, Islamabad for providing NMR facilities. Our gratitude also goes to the Department of Environmental Sciences, University of Peshawar for providing FTIR facility and to the Pakistan Medical Research Center, Khyber Medical College, Peshawar (PMRC) for providing the biologic activities data.

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg