Preparation of chitosan/alginate microcapsules by high-voltage electrostatic method

Abstract

Chitosan and sodium alginate have the opposite charges; they can become a gelatin by the electrostatic attraction, High-voltage electrostatic droplet generator method was used to prepare chitosan-sodium alginate microcapsule. Multi-layer chitosan-sodium alginate microcapsule was prepared through layer-by-layer self-assembly, and the morphology was investigated. In addition, the release property of ofloxacin in microcapsules was studied by UV-Vis microscopy under different conditions such as pH value, layer number, etc. The results showed that the prepared microcapsules have a smooth surface with average particle size about 100 μm. The result of controlled release indicated that the prepared microcapsules are pH-independent, and the rate of release decreased when the layer number increases.

Keywords

chitosan / sodium alginate / electrospraying

References

[1] Vinetsky, Y.; Magdassi, S., Microencapsulations in Cosmetics. In: Magdassi S, Touitou E(eds.). Novel Cosmetic Delivery Systems. New York: Marcel Dekker, Inc., 1998, 295-313

[2] Huguet, M. L.; Groboillot, A.; Neufeld, R. J.; Poncelet, D.; Dellacherie, E., J. Appl. Polym. Sci. 1994, 51, 1427-1432

[3] Gombotz, W. R.; Wee, S. F., Adv. Drug Deliv. Rev. 1998, 31, 267-285

[4] Ramadas, M.; Paul, W.; Dileep, K. J., Ramadas, M.; Anitha, Y.; Sharma, C. P., J. Microcapsulation 2000, 17, 405-411

[5] Becherán-Marón, L.; Peniche, C.; Argüelles-Monal, W., Int. J. Biol. Macromol. 2004, 34, 127–133

[6] Murata, Y.; Kontani, Y.; Ohmae, H.; Kawashima, S., Eur. J. Pharm. Biopharm. 2002, 53, 249-251

[7] Ribeiro, A. J.; Silva, C.; Ferreira, D.; Veiga, F., Eur. J. Pharm. Sci. 2005, 25, 31-40

[8] Iwasaki, N.; Yamane, S. T.; Majima, T.; Kasahara, Y.; Minami, A.; Harada, K.; Nonaka, S.; Maekawa, N.; Tamura, H.; Tokura, S.; Shiono, M.; Monde, K.; Nishimura, S., Biomacromolecules 2004, 5, 828-833

[9] Denkbaş E. B.; Seyyal, M.; Pişkin, E., J Microencapsul 1999, 16, 741-749

[10] Jameela, S. R.; Kumary, T. V.; Lal, A. V.; Jayakrishnan, A., J. Control. Release 1998, 52, 17-24

[11] Ozbaş-Turan, S.; Akbuğa, J.; Aral, C., J Pharm Sci 2002, 91, 1245-1251

[12] Mao, H. Q.; Roy, K.; Troung-Le, V. L.; Janes, K. A.; Lin, K. Y.; Wang, Y.; August, J. T.; Leong, K. W., J. Control. Release 2001, 70, 399-421

[13] He, P.; Davis, S. S.; Illum, L., Int. J. Pharm. 1999, 187, 53-65

[14] Shi, X. Y.; Tan, T. W., Biomaterials 2002, 23, 4469-4473

[15] Pan, Y.; Li, Y. J.; Zhao, H. Y.; Zheng, J. M.; Xu, H.; Wei, G.; Hao, J. S.; Cui, F. D., Int. J. Pharm. 2002, 249, 139-147

[16] Ko, J. A.; Park, H. J.; Hwang, S. J.; Park, J. B.; Lee, J. S., Int. J. Pharm. 2002, 249, 165-174

[17] Doshi, J.; Reneker, D. H., J. Electrost. 1995, 35, 151-160

[18] Reneker, D. H.; Chun, I., Nanotechnology 1996, 7, 216-223

[19] Sukhorukov, G.; Dähne, L.; Hartmann, J.; Donath, E.; Möhwald, H., Adv. Mater. (Deerfield Beach Fla.) 2000, 12, 112-115

[20] Gao, C. Y.; Donath, E.; Möhwald, H.; Shen, J., Angew. Chem. Int. Ed. Engl. 2002, 41, 3789-3793

[21] Dähne, L.; Leporatti, S.; Donath, E.; Möhwald, H., J. Am. Chem. Soc. 2001, 123, 5431-5436

[22] Caruso, F.; Caruso, R. A.; Möhwald, H., Science 1998, 282, 1111-1114

[23] Okubo, T.; Suda, M., Colloid Polym. Sci. 2002, 280, 533-538

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