Synthesis of -amino--keto-esters (-oxodipeptides)

Abstract

The synthesis of ?-amino-?-keto-esters (?-oxo dipeptides) was studied. Corresponding ?-amino-?-keto-esters were prepared from BOC-(L)-Valine and BOC-(L)-isoleucine by coupling with (D,L)-threonine hydrochloride and oxidation with Dess-Martin periodinane (DMP) with a total yield of 48% and 38%, respectively.

References

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