Design, Characterization, and 3D Printing of Cardiovascular Stents with Zero Poisson’s Ratio in Longitudinal Deformation
Chengjin Wang, Lei Zhang, Yongcong Fang, Wei Sun
Design, Characterization, and 3D Printing of Cardiovascular Stents with Zero Poisson’s Ratio in Longitudinal Deformation
Inherent drawbacks associated with drug-eluting stents have prompted the development of bioresorbable cardiovascular stents. Additive manufacturing (3-dimentional (3D) printing) has been widely applied in medical devices. In this study, we develop a novel screw extrusion-based 3D printing system with a new designed mini-screw extruder to fabricate stents. A stent with a zero Poisson's ratio (ZPR) structure is designed, and a preliminary monofilament test is conducted to investigate appropriate fabrication parameters. 3D-printed stents with different geometric structures are fabricated and analyzed by observation of the surface morphology. An evaluation of the mechanical properties and a preliminary biological evaluation of 3D-printed stents with different parameters are carried out. In conclusion, the screw extrusion-based 3D printing system shows potential for customizable stent fabrication.
Additive manufacturing / 3D printing / Screw extrusion / Cardiovascular stent / Zero Poisson’s ratio
[[1]] |
Stettler C, Wandel S, Allemann S, Kastrati A, Morice MC, Schömig A, et al. Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis. Lancet 2007;370:937–48.
|
[[2]] |
Zhang Y, Bourantas CV, Farooq V, Muramatsu T, Diletti R, Onuma Y, et al. Bioresorbable scaffolds in the treatment of coronary artery disease. Med Devices Evid Res 2013;6:37–48.
|
[[3]] |
Wiebe J, Nef HM, Hamm CW. Current status of bioresorbable scaffolds in the treatment of coronary artery disease. J Am Coll Cardiol 2014;64:2541–51.
|
[[4]] |
Ang HY, Bulluck H, Wong P, Venkatraman SS, Huang Y, Foin N. Bioresorbable stents: current and upcoming bioresorbable technologies. Int J Cardiol 2017;228:931–9.
|
[[5]] |
Joner M, Finn AV, Farb A, Mont EK, Kolodgie FD, Ladich E, et al. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 2006;48:193–202.
|
[[6]] |
Onuma Y, Ormiston J, Serruys PW. Bioresorbable scaffold technologies. Circ J 2011;75:509–20.
|
[[7]] |
Iqbal J, Onuma Y, Ormiston J, Abizaid A, Waksman R, Serruys P. Bioresorbable scaffolds: rationale, current status, challenges, and future. Eur Heart J 2014;35:765–76.
|
[[8]] |
Stepak B, Anton´ czak AJ, Bartkowiak-Jowsa M, Filipiak J, Pezowicz C, Abramski KM. Fabrication of a polymer-based biodegradable stent using a CO2 laser. Arch Civ Mech Eng 2014;14:317–26.
|
[[9]] |
Guerra AJ, Farjas J, Ciurana J. Fibre laser cutting of polycaprolactone sheet for stents manufacturing: a feasibility study. Opt Laser Technol 2017;95:113–23.
|
[[10]] |
Guerra AJ, Ciurana J. 3D-printed bioabsordable polycaprolactone stent: the effect of process parameters on its physical features. Mater Des 2018;137:430–7.
|
[[11]] |
Martinez AW, Chaikof EL. Microfabrication and nanotechnology in stent design. WIREs Nanomed Nanobiotechnol 2011;3:256–68.
|
[[12]] |
Kaesemeyer WH, Sprankle KG, Kremsky JN, Lau W, Helmus MN, Ghatnekar GS. Bioresorbable polystatin fourth-generation stents. Coron Artery Dis 2013;24:516–21.
|
[[13]] |
Park SA, Lee SJ, Lim KS, Bae IH, Lee JH, Kim WD, et al. In vivo evaluation and characterization of a bio-absorbable drug-coated stent fabricated using a 3Dprinting system. Mater Lett 2015;141:355–8.
|
[[14]] |
Wu Z, Zhao J, Wu W, Wang P, Wang B, Li G, et al. Radial compressive property and the proof-of-concept study for realizing self-expansion of 3D printing polylactic acid vascular stents with negative poisson’s ratio structure. Materials 2018;11(8):1357.
|
[[15]] |
Wang WQ, Liang DK, Yang DZ, Qi M. Analysis of the transient expansion behavior and design optimization of coronary stents by finite element method. J Biomech 2006;39:21–32.
|
[[16]] |
Stoeckel D, Bonsignore C, Duda S. A survey of stent designs. Minim Invasive Ther Allied Technol 2002;11:137–47.
|
[[17]] |
Attard D, Grima JN. Modelling of hexagonal honeycombs exhibiting zero Poisson’s ratio. Phys Status Solidi Basic Res 2011;248:52–9.
|
[[18]] |
Masters IG, Evans KE. Models for the elastic deformation of honeycombs. Compos Struct 1996;35:403–22.
|
[[19]] |
Young WC, Budynas RG. Roark’s formulas for stress and strain. 7th ed. Beijing: Tsinghua University Press; 2003. Chinese.
|
[[20]] |
Grima JN, Oliveri L, Attard D, Ellul B, Gatt R, Cicala G, et al. Hexagonal honeycombs with zero Poisson’s ratios and enhanced stiffness. Adv Eng Mater 2010;12:855–62.
|
[[21]] |
Venkataraman N, Rangarajan S, Matthewson MJ, Harper B, Safari A, Danforth SC, et al. Feedstock material property—process relationships in fused deposition of ceramics (FDC). Rapid Prototyp J 2000;6:244–52.
|
[[22]] |
Liu B, Xie Y, Wu M. Research on the micro-extrusion characteristic of mini-screw in the screw extruding spray head. Polym Bull 2010;64: 727–38.
|
[[23]] |
Wang F, Shor L, Darling A, Khalil S, Sun W, Güçeri S, et al. Precision extruding deposition and characterization of cellular poly-e-caprolactone tissue scaffolds. Rapid Prototyp J 2004;10:42–9.
|
[[24]] |
Capone C, Di Landro L, Inzoli F, Penco M, Sartore L. Thermal and mechanical degradation during polymer extrusion processing. Polym Eng Sci 2007;47:1813–9.
|
[[25]] |
Liu C, Li Y, Zhang L, Mi S, Xu Y, Sun W. Development of a novel lowtemperature deposition machine using screw extrusion to fabricate poly(Llactide-co-glycolide) acid scaffolds. Proc Inst Mech Eng Part H J Eng Med 2014;228:593–606.
|
[[26]] |
F2606-08 Standard guide for three-point bending of balloon expandable vascular stents and stent systems. US Standard. West Conshohocken: American Society of Testing Materials; 2014.
|
[[27]] |
F3067-14 Guide for radial loading of balloon expandable and self expanding vascular stents. US Standard. West Conshohocken: American Society of Testing Materials; 2014.
|
[[28]] |
Wang Q, Fang G, Zhao Y, Wang G, Cai T. Computational and experimental investigation into mechanical performances of poly-L-lactide acid (PLLA) coronary stents. J Mech Behav Biomed Mater 2017;65:415–27.
|
[[29]] |
Schmidt W, Behrens P, Brandt-Wunderlich C, Siewert S, Grabow N, Schmitz KP. In vitro performance investigation of bioresorbable scaffolds—standard tests for vascular stents and beyond. Cardiovasc Revascularization Med 2016;17:375–83.
|
[[30]] |
Schmidt W, Lanzer P, Behrens P, Topoleski LDT, Schmitz KP. A comparison of the mechanical performance characteristics of seven drug-eluting stent systems. Catheter Cardiovasc Interv 2009;73:350–60.
|
[[31]] |
Colombo A, Stankovic G, Moses JW. Selection of coronary stents. J Am Coll Cardiol 2002;40:1021–33.
|
[[32]] |
F756-17 Standard practice for assessment of hemolytic properties of materials. US Standard. West Conshohocken: American Society of Testing Materials; 2017.
|
[[33]] |
Im SH, Kim CY, Jung Y, Jang Y, Kim SH. Biodegradable vascular stents with high tensile and compressive strength: a novel strategy for applying monofilaments via solid-state drawing and shaped-annealing processes. Biomater Sci 2017;5:422–31.
|
[[34]] |
ISO 10993-5:2009 Biological evaluation of medical devices—part 5: tests for in vitro cytotoxicity. EN Standard. Geneva: International Organization for Standardization; 2009.
|
/
〈 | 〉 |