Hypomagnesemia: the 12th pitfall in interpreting hyperlactatemia in sepsis

Thanh Luan Nguyen , Phuc Tuong Pham , Van Hoang Nam Ho

Emergency and Critical Care Medicine ›› 2026, Vol. 6 ›› Issue (1) : 3 -5.

PDF (789KB)
Emergency and Critical Care Medicine ›› 2026, Vol. 6 ›› Issue (1) :3 -5. DOI: 10.1097/EC9.0000000000000163
Perspectives/Viewpoints
research-article
Hypomagnesemia: the 12th pitfall in interpreting hyperlactatemia in sepsis
Author information +
History +
PDF (789KB)

Cite this article

Download citation ▾
Thanh Luan Nguyen, Phuc Tuong Pham, Van Hoang Nam Ho. Hypomagnesemia: the 12th pitfall in interpreting hyperlactatemia in sepsis. Emergency and Critical Care Medicine, 2026, 6 (1) : 3-5 DOI:10.1097/EC9.0000000000000163

登录浏览全文

4963

注册一个新账户 忘记密码

Conflict of interest statement

The authors declare no conflict of interest.

Author contributions

The authors conceived the concept, performed the literature review, wrote the manuscript, and approved the final version.

Funding

None.

Ethical approval of studies and informed consent

Not applicable.

Acknowledgements

None.

References

[1]

Garcia-Alvarez M, Marik P, Bellomo R. Sepsis-associated hyperlactatemia. Crit Care. 2014; 18(5):503. doi:10.1186/s13054-014-0503-3

[2]

Gattinoni L, Vasques F, Camporota L, et al. Understanding lactatemia in human sepsis. Potential impact for early management. Am J Respir Crit Care Med. 2019; 200(5):582-589. doi:10.1164/rccm.201812-2342OC

[3]

Hernandez G, Bellomo R, Bakker J. The ten pitfalls of lactate clearance in sepsis. Intensive Care Med. 2019; 45(1):82-85. doi:10.1007/s00134-018-5213-x

[4]

Ricci Z, Romagnoli S. The 11th pitfall: thiamine deficiency. Intensive Care Med. 2018; 44(9):1597. doi:10.1007/s00134-018-5271-0

[5]

Touyz RM, de Baaij JHF, Hoenderop JGJ. Magnesium disorders. N Engl J Med. 2024; 390(21):1998-2009. doi:10.1056/NEJMra1510603

[6]

Wolf FI, Cittadini A. Chemistry and biochemistry of magnesium. Mol Aspects Med. 2003; 24(1-3):3-9. doi:10.1016/s0098-2997(02)00087-0

[7]

Gray LR, Tompkins SC, Taylor EB. Regulation of pyruvate metabolism and human disease. Cell Mol Life Sci. 2014; 71(14):2577-2604. doi:10.1007/s00018-013-1539-2

[8]

Noormandi A, Khalili H, Mohammadi M, Abdollahi A. Effect of magnesium supplementation on lactate clearance in critically ill patients with severe sepsis: a randomized clinical trial. Eur J Clin Pharmacol. 2020; 76(2):175-184. doi:10.1007/s00228-019-02788-w

[9]

Tonai K, Katayama S, Koyama K, Imahase H, Nunomiya S. Association between hypomagnesemia and serum lactate levels in patients with sepsis: a retrospective observational study. J Anesth Analg Crit Care. 2024; 4(1):23. doi:10.1186/s44158-024-00158-2

[10]

Moskowitz A, Lee J, Donnino MW, Mark R, Celi LA, Danziger J. The association between admission magnesium concentrations and lactic acidosis in critical illness. J Intensive Care Med. 2016; 31(3):187-192. doi:10.1177/0885066614530659

[11]

Donnino MW, Andersen LW, Chase M, et al. Randomized, double-blind, placebo-controlled trial of thiamine as a metabolic resuscitator in septic shock: a pilot study. Crit Care Med. 2016; 44(2):360-367. doi:10.1097/CCM.0000000000001572

[12]

Weiss SL, Blowey B, Keele L, et al. Matched retrospective cohort study of thiamine to treat persistent hyperlactatemia in pediatric septic shock. Pediatr Crit Care Med. 2019; 20(9):e452-e456. doi:10.1097/PCC.0000000000002074

PDF (789KB)

0

Accesses

0

Citation

Detail

Sections
Recommended

/