Klotho mitigates intervertebral disc degeneration by regulating autophagy and energy metabolism

Md Entaz Bahar; Trang Huyen Lai; Jin Seok Hwang; Quang Nhat Ngo; Rizi Firman Maulidi; Jinsung Yang; Wanil Kim; Seung Pil Yun; Dong-Kun Lee; June-Ho Byun; Deok Ryong Kim

doi:10.1002/ctm2.70371

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (6) :e70371 DOI: 10.1002/ctm2.70371

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Klotho mitigates intervertebral disc degeneration by regulating autophagy and energy metabolism

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Md Entaz Bahar, Trang Huyen Lai, Jin Seok Hwang, Quang Nhat Ngo, Rizi Firman Maulidi, Jinsung Yang, Wanil Kim, Seung Pil Yun, Dong-Kun Lee, June-Ho Byun, Deok Ryong Kim. Klotho mitigates intervertebral disc degeneration by regulating autophagy and energy metabolism. Clinical and Translational Medicine, 2025, 15(6): e70371 DOI:10.1002/ctm2.70371

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References

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[1]	Wang F, Cai F, Shi R, Wang XH, Wu XT. Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration. Osteoarthr Cartil. 2016; 24(3): 398-408.

[2]	Feng C, Liu H, Yang M, Zhang Y, Huang B, Zhou Y. Disc cell senescence in intervertebral disc degeneration: causes and molecular pathways. Cell Cycle. 2016; 15(13): 1674-1684.

[3]	Ma WZ, Wang WT, Zhao L, et al. Reprogramming to restore youthful epigenetics of senescent nucleus pulposus cells for mitigating intervertebral disc degeneration and alleviating low back pain. Bone Res. 2025; 13(1).

[4]	Lim K, Halim A, Lu TS, Ashworth A, Chong I. Klotho: a major shareholder in vascular aging enterprises. Int J Mol Sci. 2019; 20(18).

[5]	Zhou HJ, Zeng CY, Yang TT, Long FY, Kuang X, Du JR. Lentivirus-mediated klotho up-regulation improves aging-related memory deficits and oxidative stress in senescence-accelerated mouse prone-8 mice. Life Sci. 2018; 200: 56-62.

[6]	Zhou H, Pu S, Zhou H, Guo Y. Klotho as potential autophagy regulator and therapeutic target. Front Pharmacol. 2021; 12: 755366.

[7]	Yi YY, Chen H, Zhang SB, Xu HW, Fang XY, Wang SJ. Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/PAK1/MMP-2 signaling axis. Mech Ageing Dev. 2022; 207: 111715.

[8]	Zhang YL, Zhang Z, Chen PK, et al. Directed differentiation of notochord-like and nucleus pulposus-like cells using human pluripotent stem cells. Cell Rep. 2020; 30(8): 2791-2806.

[9]	Wu YJ, Li S, Shen JL, Wang ZY, Liu H. Nucleus pulposus related lncRNA and mRNA expression profiles in intervertebral disc degeneration. Genomics. 2023; 115(2).

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.