Stereo-cell is a newly developed platform for spatial single-cell sequencing that integrates morphology, transcriptomics, and proteomics in high resolution. By preserving spatial context while enabling multimodal profiling, it bridges the gap between advanced omics and traditional pathology, supporting the detection of rare cells and clinically interpretable diagnoses. This letter highlights the technical innovations of Stereo-cell, its positioning within the spatial omics landscape, and its potential for precision medicine. Important challenges in data integration, regulatory compliance, and digital modelling are discussed as essential steps on the path to clinical implementation.
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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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